Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
28 Cards in this Set
- Front
- Back
|
5-FU
Capecitabine |
uracil copycat - stops thymidylate sythase - folinic acid potentiates
Breast, Skin, GI |
|
|
Pemetrexed
|
folate copycat - stops thymidylate synthase - give with Vit B12 and folate
Breast, Lung |
|
|
6-MP
Azathioprine |
metabolites that inhibit IMPDH blocking AMP and GMP synthesis - allopurinol potentiates
ALL, AML, Crohn's Immunosuppresion |
|
|
Pentostatin
|
metabolites that inhibit IMPDH blocking AMP and GMP synthesis - selectively inhibits adenosine deaminase
Hairy Cell Lymphoma |
|
|
Hydroxyurea
|
blocks ribonucleotide reductase
Blood, Head, Melanoma, Ovary, Sickle Cell |
|
|
Thioguanine
|
Guanine copycat
AML |
|
|
Fludarabine Phosphate
|
Purine nucleotide copycat
CLL, lymphoma |
|
|
Cladribine
|
Purine copycat
Hairy Cell, Multiple Sclerosis |
|
|
Cytarabine
|
Cytidine copycat
ALL, AML, CML, meningeal leukemia, Lymphoma |
|
|
Azacytidine
|
Cytidine copycat
Myelodysplastic Sx |
|
|
Gemcitabine
|
Cytidine copycat
Pancreas, Lung, Breast, Ovary, Bladder, Sarcoma, Hodgkin's |
|
|
Cyclophosphamide
|
Alkylater - Give with Mesna to prevent hemorrhagic cystitis
Immunosupression, Leukemia, Lymphoma, Mycosis fungoides, Neuroblastoma, Malignant histiocytosis, Ovary, Retina, Breast, |
|
|
Mechlorethamine
|
Alkylater
Leukemia, Hodgkin's |
|
|
Melphalan
|
Alkylater
Lymphoma |
|
|
Estramustine
|
Alkylater
Prostate |
|
|
Chlorambucil
|
Alkylater
Leukemia |
|
|
Mitomycin
|
Alkylater
Pancreas, Stomach |
|
|
Thiotepa
|
Alkylater - instilled directly into bladder
Bladder |
|
|
Carmustine
|
Alkylater
Brain |
|
|
Dacarbazine
Procarbazine |
Alkylater
Hodgkin's |
|
|
Altretamine
|
Alkylater
Ovary |
|
|
Cisplatin
Carboplatin |
Platinums - Cisplatin can be injected intraperitoneally for Ovarian Cancer - Give with Amifostine to limit Kidney Damage
GU, Ovary, Lung |
|
|
Oxaliplatin
|
Platinum - Neurotoxicity is worsened by cold temps
Colon |
|
|
Bleomycin
|
binds Oxygen and chelates Iron - effects on lung function are irreversible
Testicles, Lymphoma, Squamous Cell |
|
|
Irinotecan
Topotecan |
Topoisomerase 1 blockers (camptothecins) - Life-threatening Diarrhea
Colon (Irinotecan) Small Cell, Cervical, Ovary (Topotecan) |
|
|
Doxorubicin
Daunorubicin Epirubicin Etoposide Teniposide Amsacrine |
Topoisomerase 2 blockers (anthracyclines) - excreted in bile - don't use in patients with Heart Failure
Leukemia, Lymphoma, Breast, Bladder, Ovary, Thyroid, GI, Nephroblastoma, Osteosarcoma, Small Cell, Sarcoma (Doxorubicin) ALL, AML (Daunorubicin) Breast (Epirubicin) Testes, Lung, Leukemia (Etoposide) ALL, Lymphoma (teniposide) Leukemia, Ovary (Amsacrine) |
|
|
Vinblastine
Vincristine |
Blocks Microtubule Polymerization - don't give Vincristine to Charcot-Marie-Tooth Patients
Testes, Choriocarcinoma, Lymphoma, Breast, Malignant Histiocytosis, Kaposi's, Mycosis fungoides (Vinblastine) Leukemia, Lymphoma, Rhabdomyosarcoma, Nephroblastoma (Vincristine) |
|
|
Paclitaxel
Docetaxel |
Blocks Microtubule Depolarization
Ovary, Breast, Lung, Kaposi's (Paclitaxel) Breast, Stomach, Prostate, Lung (Docetaxel) |
