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23 Cards in this Set
- Front
- Back
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enlarged lysosome, impaired chemotaxis; pyogenic infx. syndrome?
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Chediak Higashi
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decreased H202, deficit of NADPH oxidase; staph and serratia infx. dx?
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chronic granulomatous disease
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excessive IgE; PMNs don't respond to chemotaxis. dx?
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Job's syndrome
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most common monoclonal gammopathy; bone marrow plasma cells <5%; age >50yrs. dx?
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MGUS
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severe bone pain; hypercalcemia with normal alk phos; bleeding; kidney probs. dx?
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MM
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hyperviscosity, sludged blood due to ++ IgM; excessive thrombosis, hemorrhage, heart failure. dx?
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Waldenstrom's Macroglobulinemia
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lymphoma, hypo-immunity, eczema, low platelets, T- and B-cell immune dysfunction. dx?
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Wiskott Aldrich Syndrome
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mean ages for:
ALL CML AML CLL |
ALL: kids
CML: 42yo AML: 60yo CLL: 65yo |
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what is the LEUKEMIA mnemonic?
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Light skin (pallor)
Energy poor Underweight Kidney failure Excess fever Mottled skin (hemorrhage) Infx Anemia |
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define acute leukemia.
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proliferation of minimally differentiated BLAST cells
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define chronic leukemia.
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proliferation of more mature, differentiated cells
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define lymphocytic leukemia.
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neoplasm of lymphoid cells (B and T lymphocytes)
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define myelogenous leukemia.
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neoplasm of myeloid cells (granulocytes (BEN), monocytes, platelets, erythrocytes)
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acute onset within few weeks of diagnosis; associated with Down's syndrome; increased blasts with PAS+, TdT+, CALLA+. leukemia? median age?
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ALL
kids |
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myeloid cells at different types of differentiation; splenomegaly; about 150,000 WBCs at diagnosis; low leukocyte alk phos. leukemia? median age?
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CML
42yrs |
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sx of bone marrow failure; one type associated with DIC; another causes gingival hyperplasia; eosinphilic needle-like cytoplamic inclusions found in blast cells. leukemia? median age?
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AML
60yo |
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clonal malignancy of B lymphocytes (>98%) and T lymphocytes (2%); found via incidental finding of isolated lymphocytosis (>5,000); smudge cells. leukemia? median age?
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CLL
65yo |
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what are the types of microcytic anemia?
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TICS
Thalassemia Iron deficiency Chronic disease Sideroblastic |
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types of normocytic anemia?
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CHUB
Chronic disease Hypothyroidism Uremia Bone marrow failure (aplastic anemia) |
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types of macrocytic anemia?
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V MAL
Vitamin deficiency (B12 or Folate) Myelodysplasia Alcohol and drugs Liver dysfunction |
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describe non-Hodgkin's lymphoma.
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non-pruritic
non-contiguous lymph node spread (systemic) non-regional adenopathy |
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what is tumor lysis syndrome?
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rapid cellular death due to therapy; dump a KUP of cell juice w/o Ca++
K+ Uric acid Phosphate |
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which of the leukemias presents with problems secondary to sludging?
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AML
"A Mud-Like" problem: - neuro - CV - respiratory |
