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18 Cards in this Set
- Front
- Back
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Rapid acting insulin (3)
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lispro, aspart, glulisine
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Long acting insulins (2)
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detemir, glargine
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sulfonylureas (3)
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glyburide, glipizide, glimepiride
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Glitinides (2)
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insulin secretagoge. Repaglinide, nateglinide. No sulfur in structure thus can be given to sulfonylurea allergies.
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Biguanide (1)
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metformin. decreases endogenous glucose production.
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tolbutamide
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sulfonylurea. 1st gen, rarely used except in older diabetics because of short half-life.
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-amide
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sulfonylurea (1st gen). -ide = 2nd gen sulfonyurea.
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MOA of thiazolidinediones
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regulates gene expressino by binding to PPAR-gamma.
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rosiglitazone
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thiazolidinedione
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pioglitazone
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thiazolidinedione
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acarbose
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alpha-glucosidasde inhibitor. reduces conversion of starch and disaccharides to monosaccharides, prevents post-prandial hyperglycemia.
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miglitol
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alpha-glucosidasde inhibitor. reduces conversion of starch and disaccharides to monosaccharides, prevents post-prandial hyperglycemia.
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exentatide
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GLP-1 analogue. Reduces post-meal glucose excursions: increases glucose-mediated insulin release, lowers glucagon levels, slows gastric emptying, decreases appetite.
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sitagliptin
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DPP-4 inhibitor (blocks degradation of GLP-1). thus, GLP-1 analogue. Reduces post-meal glucose excursions: increases glucose-mediated insulin release, lowers glucagon levels, slows gastric emptying, decreases appetite.
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pramlintide
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amylin analogue. Reduces post-meal glucose excursions: , lowers glucagon levels, slows gastric emptying, decreases appetite.
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what drug class may prevent diabetes II?
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Thiazoladinediones. (pioglitazone, rosiglitazone)
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-glitazone
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Thiazoladinediones.
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Which drug class reduces hepatic glucose elevation through activation of AMP-activated protein kinase (AMPK)?
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Biguanides (metformin).
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