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7 Cards in this Set
- Front
- Back
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manifests as alterations in function of CNS and CV system
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systemic toxicity
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increased paco2 = increased toxicity d/t ?
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1. increased cerebral bld flow
2. decreased pH--decreased protein binding and increased free fraction of LA |
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s/sx of cns toxicity in order
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circumoral cyanosis
lightheadedness tinnitus visual disturbance slurring speech muscle twitching irrational conversation unconsciousness grand mal seizure coma apnea |
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CNS toxicity influenced by?
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1. potency
2. rapidity of increased in systemic bld levels 3. acidosis |
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how much more dose is needed to produce CV symptoms than CNS?
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3x more
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dose related decrease in contractility aggravated by?
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1. acidosis
2. hypercapnia 3. hypoxia |
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prolonged bowel and bladder dysfunction and paraplegia
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cauda equina syndrome
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