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13 Cards in this Set
- Front
- Back
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Drugs used for Osteoporosis
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1. Dietary Calcium & Vitamin D
2. Estrogen replacement therapy & Use of estrogen receptor agonists 3. Parathyroid Hormone 4. Calcitonin 5. Fluoride 6. Bisphosphonates |
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Alendronate
(FOSAMAX) |
Bisphosphate
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Ibandronate
(BONIVA) |
Bisphosphate
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Tiludronate
(SKELID) |
Bisphosphate
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Etidronate
(DIDRONEL) |
Bisphosphate
IV infusion used for hypercalcemia and Osteoporosis |
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Risedronate
(ACTONEL) |
Bisphosphate
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Zoledronate
(ZOMETA) |
Bisphosphate
Rare Renal Dysfunction |
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Bisphospate drugs (6)
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Alendronate (FOSAMAX)
Ibandronate (BONIVA) Tiludronate (SKELID) Etidronate (DIDRONEL) Risedronate (ACTONEL) Zoledronate (ZOMETA) |
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Bisphosphate
-MOA |
MOA
-inhibits osteoclastic activity through apoptosis (non-hydrolysable ATP analog) & -interferes with cholesterol synthesis (farnesyl synthase) in the osteoclast. |
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Bisphosphates
-Kinetics -Chronic Treatment |
Kinetics
-Have high affinity for Ca in bone matrix. -long half-life (infrequent dosing) -in the design of the bisophosphonate drugs, there is a chemical replacement of teh oxygen of teh pyrophosphate bond with a carbon. Chronic treatment enhances bone mass in osteoporosis |
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Bisphosphates
-Adverse Effects -Counterindication |
-Oral admin: GI irritation and poor absorption
-Cytokine release upon parenteral infusion (fever, aches, flu-like syndrome) -Rare renal dysfunction (zolendronate) -Rare adverse effect: cellular necrosis & osteomalacia in mandibular structures. Counterindication: Pregnancy |
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Drug treatment for Hypercalcemia
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1. Saline Diuresis (followed by furosemide, if necessary)
2. Bisphosphates (etidronate & pamidronate) as IV infusion 3. Calcitonin 4. Gallium nitrate 5. Phosphate |
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pamidronate
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Bisphosphate
IV infusion used for hypercalcemia and Osteoporosis |
