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19 Cards in this Set

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Erythropoietin
(EPOGEN, PROCRIT)

-MOA
-USES
1. kidney response to hypoxemia
2. Stimulates burst forming units (BFU-E) cells to amplify and commit to erythocyte production.

Uses:
A. RBC production (esp Renal failure)
B. normochromic - RBC color is normal
C. normocytic anemia - RBC is normal size.
D. Renal Failure and Chemo patients (Due to distruction of RBC)
Darbepoetin
(ARANESP)
1. erythropoietin analogue
2. ↑Half-life, ↓Admin frequency
Normocytic anemia
RBC is normal size as a health person
Normochromic anemia
RBC is normal color as a health person
Microcytic anemia
Hypochromic anemia
anemia specific to iron deficiency
Oral ferrous sulfate
Used in microcytic anemia & hypochromic anemia (anemia specific to iron deficiency)
Sodium ferric gluconate complex
(FERRLECIT)
Used in microcytic anemia & hypochromic anemia (anemia specific to iron deficiency)
Iron sucrose
(VENOFER)
Used in microcytic anemia & hypochromic anemia (anemia specific to iron deficiency).
Also patient has malabsroption syndrome with iron.
Iron dextran
(DexFerrum)
Used in microcytic anemia & hypochromic anemia (anemia specific to iron deficiency).
Also patient has malabsroption syndrome with iron.
deferoxamine
chelator used to reduce plasma iron due to an overdose.
Pyridoxine
vitamin B6
Pyridoxine (Vit B6) Deficiency Anemai
-Rare type of anemia.
-Occus with pyrazinamide & isoniazid treatment for tuberculosis.
-Patient has to have concurrent mal-nutrition problems (↑turnover & ↓intake)
Vitamin B12 Deficiency
-Responsible for the 1 carbon addition in nucleotide synthesis.
-Deficiency: the pro-generator cells don't develop adequately and dont divide well. (Megaloblastic anemia & Myelin Degeneration.
Due to absence of an intrinsic factor (produced by the parietal cells of the gastric mucosa) which facilitates the absorption of the vitamin.
-↓B12 → ↓RBC production. (B12 used in nucelotide synthesis)
Magaloblastic anemia
due to vitamine B12 deficency or folic acid deficiency. also get myelin degeneration leading to neurological degenration.
See magaloblast cells in the circulation trying to do the job of the RBC.
Folic Acid Deficiency
megaloblastic anemia in adults.
G-CSF
Granulocyte colony stimulating factor
(FILGRASTIM)
Stimulates progenitor cells of neutrophils
↑neutrophil life
Uses: neutropenia due to cytotoxic chemotherapy
Mobilizes stem cells into peripheral blood (for transplantation) ←stem cell harvesting.
PEGFILGRASTRIM
pegylated from of FILGRASTIM that allows for less frequent administration of the G-CSF (Grnaulocyte colony stimulating factor)
GM-CSF Sargramostim
(LEUKINE)
Granulocyte Macrophage-colony stimulating factor.

Induce neutrophil recovery (Esp: Acute myelogenous leukemia)
Adjunct for bone marrow and stem cell transplantation.
Oprelvekin
(NEUMEGA)
A. Stimulates magakaryocyte precursors → (↑platelet production)
B. Thrombocytopenia secondary to cytotoxic chemotherapy. (prevent bleeding out due to poor platelet count)
C. Heprin induce thrombocytopenia