Komiskey

Front 1

Dopaminergic Tracts that make up the Reward system of the brain? List 4

Back 1

Nigostriatal
Tuberoinfundibular
Mesolimbic
Mesocortical

Front 2

Mesolimbic System is made up of what 5 areas (that are involved with addiction)

Back 2

Ventral Tegmental
Nucleus Accumbens
Amygdala
Hippocampus
Prefrontal Cortex

Front 3

When do we have increased plasticity of our brain and increased DA levels? Be specific.

Back 3

Adolescents--- Middle adolescents (14-16) is the most vulnerable. Puberty hormones increases vulnerability too

Front 4

Increase in DA in the Prefrontal Cortex will be balanced by _______________.

Back 4

decrease in DA in Nucleus Accumbens----need more exciting stimulatnt to get same reward----give teens positive risk taking oppurtunities

Front 5

Brain circuits of addicted indiv. have _______________ shutdown leading to less inhibitory control.

Back 5

prefrontal cortex shutdown

Front 6

What peaks in volume at puberty and then prunes as we mature?

Back 6

Prefrontal Cortex- responsible for deilberative thinking, cost vs, benefit, reasoning, motivation

Front 7

Withdrawal is a CREB mediated up regulation via ___________________.

Back 7

Dynorphin stimulating kappa receptors

Front 8

Tolerance 1st:____________
Craving 2nd:______________.

Back 8

CREB
FosB

Front 9

Organic Cation Transporter (Oct-3) will have excess meth and DA taken up by __________if they become too high.

Back 9

Astrocytes

Front 10

Why do meth abusers have slow reactions, slow gait, and decrease in memory recall?

Back 10

Decrease in DA transporters

Front 11

______________ decreases glucose metabolism in the frontal and temporal lobes.

Back 11

Marijuana

Front 12

What was activated by the Cocaine video?

Back 12

Amygdala

Front 13

What was activated by Cocaine craving?

Back 13

increase in Cingulate
increase in Ant. CIngulate

Front 14

What effect do amphetamines have on the NA?

Back 14

increase release of DA

Front 15

A decrease in OFC will compromise _________________.

Back 15

assigning appropriate value.

Front 16

Inhibitory Control circuit?

Back 16

Prefrontal Cortex

Front 17

Motivated Drive?

Back 17

OFC

Front 18

Reward Center?

Back 18

VTA and NA

Front 19

Learning and Memory?

Back 19

Hippocampus
Amygdala

Front 20

Inhibitory control can be targeted for addiction therapy using what techniques?

Back 20

educations exercises
puzzles
vertical integration

Front 21

increasing the value of non-drug reinforces positive connections to others via Mirror neurones is a technique for what brain circuit?

Back 21

OFC

Front 22

OFC= Motivated Drive= _____________treatment

Back 22

Mirror Neurons

Front 23

What treatment targets the brain addictive NA and VTA?

Back 23

Buprenorphine

Front 24

What brain circuit is being targeted?
Horizontal Integ. (tell your story)
Role playing
Neuropsych
set limits

Back 24

Hippocampus and Amygdala

Front 25

Drug induced deaths due to ___________ and ___________.

Back 25

Cocaine
Meth

Front 26

Cocaine self administration is increased in _______________.

Back 26

subordinate people

Front 27

What happens to an addicted persons CRF when they stop a drug?

Back 27

Increase in CRF leading to an increase in Anxiety leading to RELAPSE

Front 28

Acute exposure of a stimulus strengthens the behavior that produces it. What is this a def. of?

Back 28

Reinforcement

Front 29

Behaviorial Plasticity in which behavorial changes occur in response to acute exposure toa reinforcing drug?

Back 29

Drug Reinforement

Front 30

Increase in response to a chronic exposure to a drug given at a constant dose?

Back 30

Sensitization (opposite of tolerance)

Front 31

What trx activates opioid receptors?

Back 31

Methadone
LAAM
Buprenophine

Front 32

What trx blocks opioid receptors?

Back 32

Naloxone

Front 33

What trx activates nicotinic receptors?

Back 33

Nicotine gum/patches

Front 34

Knowledge + Emotion= Gene Change. THis is known as _____________.

Back 34

Neurogenesis

Front 35

Substantia Nigra and VTA react to surprise and release DA. What is this called?

Back 35

Novelty

Front 36

Increase in neurogenesis in the Hippocampus by social enrichment, recovery housing, church and social intervention. What is this called?

Back 36

Environement Enrichment

Front 37

increase in DA D2 receptors in the hippocampus due to social intervention is called what?

Back 37

Environmental Enrichment

Front 38

Acute Drug Administration causes ______________________.

Back 38

increase in DA neurotransmission

Front 39

Chronic Drug Administration causes _____________.

Back 39

decrease in DA activity and deregulation of frontal brain

Front 40

Decrease in DA D2 receptors ____________risk for drug use.

Back 40

INCREASES risk

Front 41

What picks up other peoples empathy and is involved in intuition and imitation?

Back 41

Mirror Neurons

Front 42

Most of neuropsychosocial rehab is during ___________.

Back 42

Time of greatest dysfunction.

Front 43

Recovery is ___________ dependent.

Back 43

TIMING