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70 Cards in this Set
- Front
- Back
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medullary lytic lesion with circumferential layer of reactive bone
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this is "onion skin" pattern seen in Ewing's sarcoma
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sunburst pattern in distal femur
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osteosarcoma
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a tumor probably very rich in prostaglandins
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osteoid osteoma
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pain is worse at night and after drinking but responds to aspirin
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osteoid osteoma
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very rapidly expanding lesion with dilated vascular channels and granulation tissue
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aneurysmal bone cyst
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lesion with lucent "ground glass" appearance on XR and haphazardly arranged bone trabeculae
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fibrous dysplasia (all woven bone with spindle cells and fibrous background)
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irregularly thickened bone cortex; very lg abnormal osteoclasts; high output heart failure
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Paget's disease
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depressed pt with kidney stones and irregular bowel movements
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osteitis fibrosa from parathyroid adenoma
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von Kossa stain on bone bx shows lots of black but also lots of pink
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osteomalacia (black is calcium; pink is non-calcified osteoid)
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bx shows large cells with foamy eosinophilic cytoplasm and indented nuclei
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Langerhands cell histiocytosis
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osteomyelitis occurs most often in what bone region?
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metaphysis, b/c that's where arteries cureve around (~stasis)
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blue sclera
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osteogenesis imperfecta
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"marble bone"
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osteopetrosis
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osteopetrosis due to?
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impaired osteoclast function
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lesion grows AWAY from jnt/bone; del 8q
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osteochondroma (Ring of Ranvier defect)
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primary site of injury in osteoarthritis?
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articular cartilage
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acellular eosinophilic material surrounded by foreign-body giant cells + podagra =
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gout
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biphasic histology with darker spindly mesenchymal cells and lighter epithelioid cells =
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synovial sarcoma
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t(x;18)
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synovial sarcoma
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mediastinal mass + EOM weakness=
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thymoma and myasthenia gravis
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gradually increasing symmetric proximal muscle weakness
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polymyositis
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dermatomyositis, esp in men, assoc'd with ?
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underlying malignancy
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target of autoimmune reaction in dermatomyositis?
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blood vessels in/around muscle. Get immune complex deposition and indirect injury to muscles
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ATPase stain showing "fiber type grouping"
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denervation followed by renervation
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ATPase stain shows degenerated muscle fibers (both types) and also some v. hypertrophic type 1 bundles
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spinal muscle atrophy (get degeneration of anterior horn cells)
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single file infiltrating tumor cells in breast
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invasive lobular carcinoma (abnl mammogram but no discrete mass)
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lg pale cells amongst keratinocytes of nipple
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Paget's disease
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Paget's boobie disease assoc'd with?
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underlying ductal carcinoma
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cribiform pattern
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ductal carcinoma
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path findings in intraductal papilloma
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bloody nipple discharge, cystic space, papillary lesion in subareolar duct
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elongated epithelial duct structures in loose myxoid stroma
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fibromadenoma
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pap smear with high grade dysplasia (high nuclear/cytoplasm) assoc'd with?
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HPV type 16 or 18
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uterine contents: very large edematous chorionic villi with no trophoblastic proliferation and also normal villi
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partial mole (assoc'd with triploidy)
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H/O hydatidiform mole is increased risk for what?
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choriocarcinoma
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lg villi with edema and ~no vasculature, trophoblastic proliferation
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hydatidiform mole
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Call-Exner bodies seen in what gyn cancer?
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granulosa cell tumor
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atypical surface epithelium, some papillary structure, more than 1 cell layer think epi but no invasive = what gyn cancer?
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borderline tumor
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ovarian mass with very uniform tall columnar, non ciliated cells
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mucinous cystadenoma
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ovarian mass with very uniform ciliated columnar epithelium
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serous cystadenoma
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grossly thickened myometrium with whitish nodules that plug up myometrial vessels
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endometrial stromal sarcoma
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chocolate cysts
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endometriosis
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histology of endometriosis
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glandular structures embedded in dense stroma
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hobnail cells assoc'd with?
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pregnant uterus
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abnl pap smear: mosaic surface epithelium (like inlaid tile floor)
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think cervical dysplasia
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"bunch of grapes" protruding from young girl's vagina
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sarcoma botryoides
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DES exposure in utero-->
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clear cell adenocarcinoma (solid sheet of tumor cells with abundant clear cytoplasm)
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irregular densities on mammogram but no discrete mass appreciated most likely
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fibrocystic change
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lymphoepithelial lesions in parotid gland
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Sjogren's
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histology of pleomorphic adenoma (parotid gl)
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nests of epithelial cells along with myxoid/cartilaginous cells
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histo of nasal polyps
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respiratory epithelium, loose edematous stroma with inflammatory infiltrate and lots of eosinophils
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NK cell type
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think lethal midline granuloma (angiocentric and angiodestructive cellular infiltrate)
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tumor with fibrous collagenous stroma and slitlike vascular spaces
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nasopharyngeal angiofibroma (adolescent boys!)
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most frequent of all tumors in Chinese?
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nasopharyngeal carcinoma (EBV assoc'd with nonkeratinizing type)
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histology of superficial dermal vessel in hypersensitivity angiitis
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vessel is surrounded by pink fibrin and PMNs, many of which have disintegrated (leukocytoclasis)
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chronic inflammation, giant cells, severely narrowed lumen
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giant cell arteritis
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chronic inflammation of pulmonary vessel, with giant cells
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Wegener's
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suprabasal bulla
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pemphigus vulgaris (desmoglein!)
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blisters on medial thighs and extensor surfaces
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bullous pemphigoid (subepidermal bulla)
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IgA deposition at dermal papilla tips
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dermatitis herpetiformus
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apoptotic keratinocytes with surrounding spongiosis and mild superficial inflammation
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erythema multiforme (target lesions on hands)
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bandlike lymphocytic infiltrate with disruption of dermal-epi junction
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lichen planus (5 p's!)
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saw tooth rete ridges
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lichen planus
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spongiosis and superficial perivascular infiltrate
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contact dermatitis (poison ivy!, type IV)
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zonal necrobiosis within dermal collagen, surrounded by palisading macrophages
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granuloma annulare
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lamellar fibrosis and nests of atypical melanocytes
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dysplastic nevus
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flat pigmented lesion on sole of foot
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acral lentiginous melanoma
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atrophic epithelium with marked cytologyic atypia of keratinocytes + scaly flaky erythematous on sun regions
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actinic keratosis
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"stuck on"
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seborrheic keratosis
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neuroendocrine differentiation on nose
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Merkel cell carcinoma
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proliferating spindle cells with ill-defined vascular spaces
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Kaposi sarcoma (HHV8)
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