Klebsiella, Pasteurella, Mannheimia

Front 1

Klebsiella are commensal opportunists T/F

Back 1

T

Front 2

A prominent hyper-mucoid capsule contributes to Klebsiella's virulence T/F

Back 2

T complement, phagocy evasion

Front 3

The capsule of klebsiella targets epithelial cells where

Back 3

urinary n respiratory tracts

Front 4

the endotoxin Lipid A causes what pathologies?

Back 4

fever, neutropenia, petechia, shock

Front 5

Klebsiella enterotoxin is similar to E coli ____ toxin

Back 5

stable toxin (ST) - causes fluid loss from epithelial cells

Front 6

Case fatality from bovine mastitis by Klebsiella is as high as

Environmental factors for transmission

Back 6

80%

moist bedding, trauma from malfunctioning milking machine

Front 7

Apart from vaginitis, Klebsiella can cause what in equines?

How is it transmitted?

Back 7

infertility, metritis, abortion

stallions, fomites, vaginal speculum

Front 8

What is navel ill in equines?

Back 8

septicemia, septic arthritis
pneumonia
pyelonephritis (renal pelvis)
productive omphalitits (pus from navel)

common with failed passive transfer of Ab

Front 9

Klebsiella in dogs cause

Back 9

pyometra, cystitis, prostatitis, enteritis, mastitis
pneumonia
meningoencephalitis
hepatic abscessation

Front 10

Klebsiella in pet birds cause

In reptiles?

In humans?

Back 10

respiratory infections
septicemia
diarrhea

pneumonia, hypopyon (pus inside eye)

UTI (nosocomial)

Front 11

klebsiella hyper-mucoid capsule causes virulence in Green Vervets how?

Back 11

resistant to oxidative killing
adherence, uptake, survival inside, and killing of monocytes

Front 12

This species of Pasteurella causes septicemia and pneumonia in sheep.

Back 12

Bibersteinia trehalosi

Front 13

P. multocida causes pneumonia in these animals

Back 13

ruminants
swine
lab animals

Front 14

T/F Mannheimia hemolytica causes septicemia and pneumonia in cattle

Back 14

F, not septicemia

Front 15

Name 1 type of adhesin and 3 capsule proteins found in host tissues expressed by Pasteurella/Mannheimia.

Back 15

fibrinogen-binding proteins (protect against C and Abs)

hyaluronic acid
heparin
chondroitin

Front 16

Name 2 siderophores of Pasteurella/Mannheimia

Back 16

Multicidin in P. multocida

OMP - binds to transferrin, heme, hemoglobin

Front 17

Leukotoxin, an RTX toxin, is produced by what species?

What does it cause?

Back 17

M. hemolytica, B. trehalosi

kills WBCs, RBCs
drives a tissue destructive inflamm response (tox granules, cytokines)

Front 18

Dermonecrotizing toxin of P. multocida type D responsible for atrophic rhinitis in swine

Back 18

PMT (a Rho-activating toxin -> incr intracellular Ca)

Front 19

Probably role of the Pasteurella/Mannheimia hyaluronidase, neuraminidase toxins

Back 19

aid in colonisation

Front 20

Why are Pasteurella/Mannheimia so resistant?

Back 20

P. multocida survives for mos in bird carcasses
R plasmid
They have multiple capsular and somatic serotypes

Front 21

What are ways of transmission for Pasteurella/Mannheimia?

Back 21

inhalation, ingestion, bites, scratchwounds (e.g. if animal had licked paws)

endogenous infection

Front 22

Where are endogenous Pasteurella/Mannheimia found?

Back 22

mucous membranes in oropharyngeal region

Front 23

What are the 3 general pathogenic manifestations of Pasteurella/Mannheimia?

Back 23

respiratory tract
septicemia
trauma associated

Front 24

Give examples of respiratory pathology in swine and cattle for Pasteurella/Mannheimia

Back 24

Cattle: commensal bact from URT infect lungs -> pneumonia -> intense inflam response (MØ, NØ, fibin deposition, RBCs) due to leukotoxin, LPS, iron-scavening prots -> red/pink/grey with abscess formation

Swine: PMT destroys nasal tissue
chronic rhinitis (disturbed osteogenesis)

Front 25

Give examples of septicemic pathology in ruminant and avian for Pasteurella/Mannheimia

Back 25

Pasteurella species: capsule, OMP, iron-scavening prot -> endotoxemia

Cattle: hemorr septicemia
Sheep: septicemia
Avian: cholera

Front 26

Give examples of trauma associated pathology for Pasteurella/Mannheimia

Back 26

Mouth bacteria associated (Pasteurella)
bite wounds
licking wounds

NØ involvement

Front 27

What's shipping fever?

Back 27

extremely important diseases accounting for 30% of cattle deaths worldwide

fibrinous pleuropneumonia or bronchopneumonia by M. hemolytica mainly, also P. multocida

caused by stress, concurrent infections etc

1-2 wks after stress -> fever, nasal discharge, cough, death

Front 28

Hemorrhagic septicemia (by P. multocida) in cattle is common in the tropics. Give some causes and symptoms.

Back 28

drastic weather changes, malnutrition, overcrowding

fever, subq edema, hypersalivation, diarrhea, sudden death

Front 29

Mastitis in cattle (M. hemolytica mainly, also P. multocida) has high mortality and is characterized by

Back 29

severe necrosis
hemorrhages
systemic implications

Front 30

Mastitis in ovine/caprine (M. hemolytica, B. trehalosis) has high mortality and is characterized by

Back 30

necrosis (blue bag) that may slough, usually in late lactation

acute systemic rxn

Front 31

Septicemia in lambs is caused by M. hemolytica and B. trehalosis and resembles

Back 31

bovine hemorrhagic septicemia

Front 32

What disease in sheep resembles bovine shipping fever commonly presenting with nasal mucus discharge and lung necrosis with bloody, purulent secretions?

Back 32

enzootic pneumonia by M. hemolytica

Front 33

Chronic atrophic rhinitis with secondary fibrous pneumonia in swine is caused by which 2 bact?

Affects pigs younger than

Back 33

Bordetella bronchoseptica (mainly) and Pasteruella multocida

7 mos

Front 34

What are the most important bact diseases in rabbits?

What can it cause?

What can trigger?

Back 34

respiratory aka "snuffles" (P. multocida)

mucopurulent rhinosinusitis
sometimes conjunctivitis, metritis, otitis media, neurologic, abscesses in lungs and skin

pregnancy, lactation, stress

Front 35

Orchitis, balanoposthitis, and pyometra are genital diseases that are caused by ________ in rabbits

Back 35

Pasteurella multocida

Front 36

How is fowl cholera (turkey, chicken, waterfowl) transmitted?

Back 36

by ingestion or inhalation of P. multocida

Front 37

What are the differences b/w per-acute, acute, sub-acute, and chronic fowl cholera?

Back 37

per-acute: 60% mortality, few signs
acute: 30% mort, anorexia, sluggish, nasal/ocular discharge, diarrhea
sub-acute: respiratory, mucopurulent nasal discharge
chronic: suppurative and caseous lesions in various places

Front 38

What can Pasteurella cause in dogs and cats?

Back 38

mouth-related conditions (infected wounds, foreign bodies)

Front 39

Equine respiratory infection with P. caballi is usually associated with

Back 39

Streptoc equi

Front 40

What dz does P. multocida cause in rodents and humans?

How transmission to humans?

Back 40

opportunistic pneumonia in rodents
local (skin) or generalized such as respiratory

bites scratches

Front 41

What vaccines are available for Pasteurella/Mannheimia prevention?

Back 41

bovine hemorrh septicemia vaccine - effective
avian - inconsistent
swine - effective bacterins containing toxoid for atrophic rhinitis

Front 42

What is a biochemical difference b/w Pasteurella and Mannheimia?

Back 42

Pasteurella ferment D-mannose, Mannheimia do not

Front 43

T/F V factor-dependent Pasteurella grows better on chocolate agar

Back 43

T