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6 Cards in this Set
- Front
- Back
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These neurons are sensitive to hypoxia |
CA1 hippocampus pyramidal neurons Cerebellar Purkinje neurons Medium spiny striata neurons Pyramidal neurons in layers 3, 5, 6 of neocortex |
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Adverse effects of HACA |
Hypokalemia Hyperglycemia Cold diuresis
If cooled <32C Brady cardia Ventricular arrhythmia Low cardiac function Immunocompromise Coagulopathy Increased blood viscosity |
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Presence of the following guarantees poor functional outcome or death if patient not cooled (based on AAN) |
No pupillary or corneal reflexes on day 3 Bilateral ext posturing or absent motor responses on day 3 Myoclonus status epilepticus within 24 hours (jerking, not EEG) Serum neuron-specific enolase >33ug/L on days 1-3 SSEPs showing bilaterally absent N20 responses |
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These 3 findings provide certainty of poor outcome with no false positives |
Bilaterally absent N20 responses on SSEPs Interactive EEG Combination of early myoclonus and absent pupillary or corneal reflexes |
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Recommended CO2 and PaO2 to prevent secondary neurologic injury |
Maintain PaCO2>35 and minimum necessary PaO2, avoid PaO2 >200mm Hg |
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Recommended SjvO2 or PbtO2 to avoid secondary neurologic injury |
SjvO2 >60% PbtO2 >20mm Hg |
