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25 Cards in this Set
- Front
- Back
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What are the microscopic rate constants?
What are the hybrid rate constants |
microscopic = k, k12, k21
hybrid = alpha & beta |
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True/False
Bioequivalent products are exact copies of brand products. |
False - not exact copies (they only need to have the same performance characteristics)
Generics are exact copies of brand products. |
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What's the difference between diffusion-limited and perfusion-limited?
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Diffusion-limited: slow diffusion into tissues
Perfusion-limited: fast diffusion into tissues |
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Give an example of a drug for Restrictive elimination?
example for non-restrictive elimination? |
Restrictive elimination: Phenylbutazone
Non-restrictive elimination: Propranolol |
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True/False
Clearance decreases when Vd and/or protein-binding increases |
True
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What are the determinants of protein binding?
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-physiochemical properties of drug & protein
-concentration or amount of drug & protein -affinity or association constant between drug & protein Interactions: competition of binding site between 2 drugs & alteration of protein by drug affecting the binding of other drugs -pathophysiology of patient |
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Ka indicates _________ of protein binding.
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strength
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What are the reversible forces of protein-drug complex?
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Van der waals and H-bonds
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What is the major reversible plasma protein? (it binds mainly weak anionic drugs)
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Albumin
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________ & ________ are the 2 blood vessels that carry blood to the liver.
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Hepatic artery & Portal vein
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True/False
The liver can self-repair and regenerate damaged tissues. |
True
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True/False
If F is not 1, and drug is 100% absorbed after oral administration, this is evidence of First Pass Effect |
True
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Name 3 drugs with extensive First Pass Effect?
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Propranolol
Nitroglycerin Morphine |
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What is the definition of a highly soluble drug?
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highest dose strength is soluble in <250ml water over pH range 1 - 7.5
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What is the definition of a highly permeable drug?
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extent of absorption is > 90% of administered dose
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What is the definition of a rapidly dissolving drug?
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> 85% of labeled amount dissolves within 30min. in volume < 900ml buffer solution with apparatus I or II
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True/False
Class 2 drug has low permeability and high solubility |
False
Class 2 = high permeability and low solubility Class 3 = low permeability and high solubility |
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What is the S factor?
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salt form of a drug
(assume S=1, unless otherwise stated) |
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True/False
The GI tract is part of the systemic compartment? |
False
Not part of the systemic compartment; considered to be an external compartment from the pharmacokinetic point of view. |
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Name the type of equation:
C = 30exp-3.3t + 10exp-0.5t |
two compartment IV
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Name the type of equation:
C = 15exp-4t - 15exp-8t |
one compartment oral absorption
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True/False
In Semilog Cp vs. t, If the peak concentration is well above the extrapolated line of the terminal slope, the plot represents a two or higher compartment model. |
True
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What is the Saunders and Natunen Method?
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(Y4-Y3)/Y3 < 0.1
If this inequality is satisfied, the one compartment model is used. If not, the two compartment model is used. |
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Which method is more suitable for disease-related cases, the PK Compartment Model or the Physiologic Model?
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Physiologic Model
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True/False
To achieve accumulation of drug in blood, k > ka |
False
ka > k |
