Kinetics Lecture 11-11 Part 27

Front 1

Steady-state Levels vs. PK-parameters

Both c(inf)max and c(inf)min are

Back 1

--directly proportional to the dose D0
--indirectly proportional to the volume of distribution VD

Front 2

steady state levels: elimination rate constant and dosing interval

Steady-state levels increase rapidly if:

Back 2

the value of the product ke * T is decreased below about 0.7

Front 3

steady state levels vs half life

for one compartment situations:

Back 3

t 1/2 = ln2/ke

Front 4

steady state levels vs half life

substitution instead of ke
(eq)

Back 4

ke * T= 0.693 * T/ t 1/2 < 0.7

0.7 = the conditin for the drug accumulation

Front 5

steady state levels vs half life

significant accumulation if the dosing interval is shorter than the half-life

Back 5

T < t 1/2


multiples of 24 (3*8, 4*6...)
dosages that are shorter than half life

Front 6

Time Course of Drug Amountin the Body I

Time course of the plasma concentration for each dosing interval is:

Back 6

c(t) = cmax * e^-ke * t

Front 7

For each interval, the minimum plasma concentration is achieved for t = T

(eq)

Back 7

c(min)/c(max) = e ^- ke * T = f

Front 8

time course of drug amount in the body I

The drug amount at the beginning of the dosing interval will decline to the fraction f at the end of the dosing interval

Back 8

f= n(min)/n(max) = e^-ke * T
(0 < or equal f < or equal 1)

Front 9

time course of drug amount in the body II

Back 9

see slide 6, 7, 8

Front 10

minimum and maximun drug amounts VIII

Back 10

see the rest of the slides...