Kinetics

Front 1

Important in carrying the absorbed drug to the systemic circulation

Back 1

Perfusion of the GIT

Front 2

"Kitchen sink phenomenon"

Back 2

Gastric emptying time

Front 3

Normal GET

Back 3

2-3 hrs

Front 4

Period required for swallowed drug to reach the stomach and eventually empties it into the small intestine

Back 4

Gastric emptying time

Front 5

Time required for drug to have sufficient time at the absorption site for optimum absorbtion

Back 5

Transit time (residence time)

Front 6

Normal peristaltic movements

Back 6

Intestinal motility

Front 7

Hydrolyses fat/lipid soluble substances

Back 7

Bile

Front 8

Law stating movement from high conc. to low conc.

Back 8

Fick's law

Front 9

Not governed by fick's law and is capacity limited

Back 9

Transport by special carriers

Front 10

Give 2 passive diffusion

Back 10

Simple diffusion and convective absorption

Front 11

Cell drinking

Back 11

Pinocytosis

Front 12

Give 2 transport by special carriers

Back 12

Active transport and facilitated diffusion

Front 13

Determines the extent of systemic absorption

Back 13

AUCtotal

Front 14

Bioavailability is equal to 1

Back 14

Intravascular route

Front 15

Cell eating

Back 15

Phagocytosis

Front 16

Bioavailability is less than 1

Back 16

Extravascular route

Front 17

Comparing the drug to standard administered by the same route

Back 17

Relative availability

Front 18

Provides warning of possibly toxic levels

Back 18

Plasma concentration

Front 19

Comparing the drug to the dose size administered

Back 19

Absolute availability

Front 20

Time required to decrease the initial dose of drug by 50%

Back 20

Half life

Front 21

The way in which the concentration of a drug affects the rate

Back 21

Order

Front 22

The velocity with which chemical reaction occurs

Back 22

Rate

Front 23

Determine the extent and rate of the reaction

Back 23

Cmax

Front 24

Curve in the log paper of zero order kinetics

Back 24

Nonlinear

Front 25

Is a mathematic description of a biologic system

Back 25

Model

Front 26

Group of tissues with similar blood flow and drug affinity

Back 26

Compartment

Front 27

Enhance or inhibit process

Back 27

Allosteric

Front 28

3 most important parameters that can be obtained from conc vs time curve

Back 28

Peak concentration, peak time, total AUC

Front 29

Process by which a drug is carried from extracellular space to interstitial space to tissue cells

Back 29

Distribution

Front 30

Is the vehicle bringing the drug molecule to and away from the membrane

Back 30

Biological fluid

Front 31

3 fluid compartment for pharmacokinetic considerations

Back 31

Intravasal or intravascular fluid, interstitial fluid, intracellular fluid

Front 32

Obtained from whole blood by removing the soluble protein fibrinogen

Back 32

Serum

Front 33

pH of extracellular fluids

Back 33

7.4

Front 34

Transported rapidly in the circulating blood then mixed between blood and tissue fluids

Back 34

Extracellular fluids

Front 35

The surface where the drug is distributed

Back 35

Diameter

Front 36

Are barriers between morphological and functional units

Back 36

Membrane

Front 37

Surface tension of membrane

Back 37

Very low

Front 38

Amount of blood delivered to different organs

Back 38

Regional blood flow

Front 39

Restricts permeation of more hydrophilic drugs into CNS

Back 39

Blood brain barrier

Front 40

Condition that will make the drug uptake into the brain enhanced

Back 40

Meningitis

Front 41

Normal cardiac output

Back 41

2.2 to 3.5 or 4.5 L/min/m2

Front 42

Duration of intravenous route

Back 42

Short

Front 43

Duration of intramuscular route

Back 43

Long

Front 44

What is the cause of blood flow accumulation

Back 44

Protein binding (dose dumping)

Front 45

Arterial end of the capillary is characterized by higher pressure, thus forces plasma and dissolved nutrients out of the capillary and into tissue fluid

Back 45

Hydrostatic pressure (filtration

Front 46

Drug combines with protein

Back 46

Protein binding

Front 47

Balance between opposing pressures in the body

Back 47

Homeostasis

Front 48

Binding to plasma proteins

Back 48

Inert binding

Front 49

Binding to tissue protein

Back 49

Receptor binding

Front 50

Help maintain blood volume and blood pressure

Back 50

Homeostasis

Front 51

2 functions of plasma proteins

Back 51

Buffer function and transport function

Front 52

What should be the dosage if the patient has acute inflammation?

Back 52

Initial dose should be increased

Front 53

What should be the dosage if the patient is undernutrition

Back 53

Reduced dosage

Front 54

Curve in the log paper in first order kinetics

Back 54

Linear