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47 Cards in this Set
- Front
- Back
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enzymes that DO NOT show genetic polymorphism
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3A4, 1A2, 2E1
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herbal supplement that doesn't cause drug interactions
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saw palmetto
goldenseal (2D6 inh) |
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Amiodarone
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inhibits 2D6 & 2C9
substrate for P-gp |
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Amitriptyline
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2D6 substrate and inhibitor
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Caffeine
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1A2 substrate
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Carbamazepine
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3A4 substrate & INDUCER
inhibits: 1A2, 2D6, 2C9, P-gp DOES NOT INHIBIT: 2E1, 2C19, OATP |
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Charbroiled Meat
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1A2 inducer
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Cigarette smoking
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1A2 and 2E1
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Cimetidine
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substrate/inhibitor for 3A4; also inhibits 1A2, 2D6, 2C9, & P-gp (everything but 2C19, 2E1, & OATP)
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ciprofloxacin
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P-gp substrate; inhibits 3A4 & 1A2
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citalopram
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2c19 substrate
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macrolides (clarith/eryth)
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sub and inh 3A4 and PgP
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codeine
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2D6 substrate
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cruciferous vegetables
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1A2 inducer
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cyclosporine
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3A4 sub
sub/inh PGP |
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dextromethorphan
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2D6 sub
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digoxin
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PGP and OATP substrate
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fexofenadine
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PGP and OATP substrate
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fluoxetine
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2D6 sub/inh
3A4 inh 2C19 inh |
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fluvoxamine
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2D6 sub
3A4, 1A2, 2C9, 2C19 inhibitor |
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grapefruit juice
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inhibits
3A4 and OATP |
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isoniazid
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2E1 sub and INDUCER
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itraconazole
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3A4 sub/inh
PGP sub/inh 2C9 inh |
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lovastatin
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3A4 and PGP
sub and inh |
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metoprolol
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2D6 sub
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midazolam
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3A4 sub only
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omeprazole
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2C19 sub/inh
3A4 inh 1A2 inducer |
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oxycodone
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2D6 substrate
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paclitaxel
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PGP substrate
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paroxetine
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3A4 inh
2D6 sub/inh |
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phenobarb
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induces
3A4, 1A2, 2C9, 2C19, PGP |
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phenytoin
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2C9 sub/INDUCER
3A4 INDUCER |
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pravastatin
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PGP and OATP substrate
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propafenone
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2D6 inh
PGP inh |
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propranolol
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2D6 sub
PGP sub |
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quinidine
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3A4 and PGP
sub and inh also inhibits 2D6 |
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rifampin
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3A4 and PGP INDUCER
1A2, 2C9, 2C19 INDUCER |
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simvastatin
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3A4 substrate
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St Johns Wort
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3A4, 2E1, 2C9, PGP
INDUCER |
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Talinolol
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PGP substrate
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theophylline
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1A2 substrate
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timolol
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2D6 and PGP substrate
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tolbutamide
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2C9 substrate
2C19 inhibitor |
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troleandomycin
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3A4 sub/inh
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verapamil
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3A4 and PGP
sub and inh |
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vinblastine
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3A4 and PGP
sub 2D6 inhibitor |
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warfarin
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1A2 sub (R)
2C9 sub (S) |
