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10 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Minimal change disease: define |
Relatively benign disorder that is characterized by diffuse effacement of foot processes of visceral epithelial cells, detectable only by electron microscopy in glomeruli that appear virtually normal by light microscopy. |
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What age is the most frequent of minimal change disease? |
The most frequent cause of nephrotic syndrome in children. |
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What points to an immunologic basis of minimal change disease? |
1.clinical association with respiratory infections and prophilactic immunization. 2. Response to corticosteroids and other immunoseppresive therapy 3. Association with other atopic disorders (eczema) 4. Increased prevalence of certain HLA associated atopy -genetic predisposition 5. Increased incidence of minimal change disease in patients with Hodgkin lymphoma |
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What is the current leading hypothesis of the mechanism of developing minimal change disese?
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A primary visceral epithelial injury Loss of glomerular polyanions. |
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What is the characteristic picture of minimal change disease by electron microscopy? |
The principal lesion is in the visceral epithelial cells, each show a uniform and diffuse effacement of foot processes. Loss of slit diaphragms. |
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When can the diagnosis of minimal change disease can be made? |
Only when effacement associated with normal glomeruli by light microscopy. |
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What is the historical name of minimal change disease? |
Lipoid nephrosis. |
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What are the changes in proximal tubules in minimal change disease? |
The cells of proximal tubules are often laden with lipid and protein, reflecting tubular reabsorption of lipoproteins passing through diseased glomeruli. |
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What are the most important clinical features of minimal change disease? |
Highly selective proteinuria- most of the protein being albumin. Dramatic response to corticosteroid therapy. |
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When minimal change disease may happen in adults? |
1. Associated with Hodgkin lymphoma . 2. Secondary, may follow NSAID therapy. |
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