Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
|
What kidn of a benign tumor has pale, yellow granules found in the CORTEX?
Do they stay benign or become malignant? |
renal papillary adenoma
Considered pre-cancerous until proven otherwise |
|
|
What kind of benign tumor will have cartilage, immature collecting ducts and poorly differentiated mesenchyme?
do they stay benign or become malignant? |
renal hamartoma (or fibroma)
no propensity for malignancy |
|
|
25-50% of patients with tuberous sclerosis have what kind of benign renal tumor?
what is tuberous sclerosis? |
angiomyolipoma
- a lesion of the brain causing epilepsy, mental retardation and skin lesions |
|
|
A renal epithelial cell tumor composed of large eosinic cells with numerous mitochrondria
|
oncocytoma
|
|
|
Renal cell carcinomas
- 3 types -Which is associated with risk of VHL disease? - pale eosinophilic cytplasm with a halo around the nucleus - associated with mutations of MET and PRCC |
- clear cell carcinoma
- chromophobe renal cell carcinoma - papillary renall cell carcinoma |
|
|
renal cell carcinomas
- associated with trisomies of chromosome 7,16,and 17 - multiple foci - single focus at the upper pole - deletion of short arm of chromosome 3 |
- papillary
- papillary - clear cell - clear cell |
|
|
Dialysis patients are at risk for developing what two bad things?
|
calcium oxalate crystals
papillary renal cell carcinoma |
|
|
Why do urotheial carcinomas of the pelvis cause obstruction and hematuria?
- patients with what tend toward urothelial carcinomas of the pelvis |
They tend to fragment causing hematuria and lead to obstruction --> hydronephrosis
ANALGESIC NEPHROPATHY PATIENTS |
|
|
benign tumor with well circumscribed yellow to mahogany color cells
|
oncocytoma
- recall this has the eosinic cytoplasm and large nucleoli and numerous mitochndria |
|
|
benign tumor associated with tuberous sclerosis
|
angiomylipoma
|
|
|
aniridia, genital malformations, and mental retaration. What is the syndrome?
What gene is responsible? What's the mutation? |
this is WAGR syndrome
WT-1 gene It's a frameshift or nonesense mutation |
|
|
gonadal dysgenesis (male pseudohermaphriditism), diffuse mesangial sclerosis. What syndrome is this?
What gene is responsible? What kind of mutation? |
Denys Drasch syndrome
WT-1 gene on chromosome 11 it's a mutation in the ZINC FINGER REGION |
|
|
What chromosome are the WT1 WT2 genes on?
|
chromosome 11 on both occaounst
|
|
|
organomegaly, macroglossia, omphalocele
What's the mutation? |
Beckwidth-Wiedmann syndrome
WT-2 gene on chromosome 11 |
|
|
What's the salient feature of wilm's tumor histology?
|
triphasic - blastemal, stromal and epithelial cell types
|
|
|
what's the precursor lesion to Wilm's tumor?
Where is it often found |
nephrogenic rests
in the contralateral kidney of a wilm's patient. |
