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20 Cards in this Set
- Front
- Back
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Sx of nephrotic syndrome
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proteinuria >3.5 g/day
hypoalbuminemia gernalized edema hyperlipidemia lipiduria |
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4 diseases of nephrotic syndrome
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minimal change (lipoid nephrosis)
membranous glomerulonephritis (nephropathy) focal segmental glomerulosclerosis membranoproliferative glomerulonephritis |
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MCC nephrotic syndrome in kids
foot process effacement selective proteinuria |
minimal change (lipoid nephrosis)
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diffuse thickening of GBM
30-50 year olds subepithelial depositis spike and dome non-selective proteinuria |
membranous glomerulonephritis
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sclerosis in some but not all glomeruli
effects parts but not all of each glomeruli affected hyalinosis |
focal segmental glomerulosclerosis
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sub-endothelial deposits
2/3 of cases |
type I membranoproliferative glomerulonephritis
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ribbon like lamina densa and subendothelial space of GBM due to deposit of unknown substance
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Type II membranoproliferative glomerulonephritis
Dense Deposit Disease |
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C3 nephritic factor
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found in Type II membranoproliferative glomerulonephritis
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Tram Trak
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Membranoproliferative glomerulonephritis
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spike and dome
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membranous glomerulonephritis
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nephritic syndrome symptoms
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hematuria
dysmorphic RBCs RBC casts oliguria azotemia hypertension |
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Nephritic syndrome diseases
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1. Acute proliferative (post-infectious) glomerulonephritis
2. rapidly progressive (crescentic) glomerulonephritis 3. IgA nephropathy (Berger disease) 4. Hereditary nephritis (alport's) 5. chronic glomerulonephritis |
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immune complexes depositing in all glomeruli of both kidneys
smoky brown urine hypocomplimentemia granular deposit of IgG sub-epithelial hump |
acute proliferative postinfectious glomerulonephritis
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formation of crescents between Bowman's capsule and glomerular tuft
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Rapidly progressive (crescentic) glomerulnephritis
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Goodpasture's
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Type I rapidly progressive (crescentic) glomerulonephritis
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immune complex mediated
lumpy bumpy staining |
type II rapidly progressive (crescentic) glomerulonephritis
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pauci immune type
no anti GBM Ab's no immune complexes pt's have ANCA (like in Wegener's or PAN) |
type II rapidly progressive (crescentic) glomerulonephritis
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kids with hematuria after upper respiratory infections
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IgA nephropathy (Berger's)
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IgA in kidney
in skin - purpuric rash in GI- abdominal pain in joints- arthritis |
Henoch-Schonlein Purpura
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20-50 yr old men
nephritis deafness eye disorders basket weave lamina densa |
Alport syndrome
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