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20 Cards in this Set

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Sx of nephrotic syndrome
proteinuria >3.5 g/day
hypoalbuminemia
gernalized edema
hyperlipidemia
lipiduria
4 diseases of nephrotic syndrome
minimal change (lipoid nephrosis)
membranous glomerulonephritis (nephropathy)
focal segmental glomerulosclerosis
membranoproliferative glomerulonephritis
MCC nephrotic syndrome in kids
foot process effacement
selective proteinuria
minimal change (lipoid nephrosis)
diffuse thickening of GBM
30-50 year olds
subepithelial depositis
spike and dome
non-selective proteinuria
membranous glomerulonephritis
sclerosis in some but not all glomeruli
effects parts but not all of each glomeruli affected
hyalinosis
focal segmental glomerulosclerosis
sub-endothelial deposits
2/3 of cases
type I membranoproliferative glomerulonephritis
ribbon like lamina densa and subendothelial space of GBM due to deposit of unknown substance
Type II membranoproliferative glomerulonephritis
Dense Deposit Disease
C3 nephritic factor
found in Type II membranoproliferative glomerulonephritis
Tram Trak
Membranoproliferative glomerulonephritis
spike and dome
membranous glomerulonephritis
nephritic syndrome symptoms
hematuria
dysmorphic RBCs
RBC casts
oliguria
azotemia
hypertension
Nephritic syndrome diseases
1. Acute proliferative (post-infectious) glomerulonephritis
2. rapidly progressive (crescentic) glomerulonephritis
3. IgA nephropathy (Berger disease)
4. Hereditary nephritis (alport's)
5. chronic glomerulonephritis
immune complexes depositing in all glomeruli of both kidneys
smoky brown urine
hypocomplimentemia
granular deposit of IgG
sub-epithelial hump
acute proliferative postinfectious glomerulonephritis
formation of crescents between Bowman's capsule and glomerular tuft
Rapidly progressive (crescentic) glomerulnephritis
Goodpasture's
Type I rapidly progressive (crescentic) glomerulonephritis
immune complex mediated
lumpy bumpy staining
type II rapidly progressive (crescentic) glomerulonephritis
pauci immune type
no anti GBM Ab's
no immune complexes
pt's have ANCA (like in Wegener's or PAN)
type II rapidly progressive (crescentic) glomerulonephritis
kids with hematuria after upper respiratory infections
IgA nephropathy (Berger's)
IgA in kidney
in skin - purpuric rash
in GI- abdominal pain
in joints- arthritis
Henoch-Schonlein Purpura
20-50 yr old men
nephritis
deafness
eye disorders

basket weave lamina densa
Alport syndrome