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14 Cards in this Set
- Front
- Back
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Morphogenesis |
organisation of cells into tissues |
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C. elegans as model organism |
genetically tractable, know lineage, transparent |
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zebrafish as model organism |
transparent eggs |
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xenopus as m.o. |
large embryo, good in microsurgery |
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Regulative development |
ability to develop normally after part of embryo removed/rearranged |
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Fate |
what a cell would normally develop into |
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Determination |
stable change in internal state of the cell - can be tested by transplantation |
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Specification |
cell can develop according to its fate even when isolated |
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Paracrine signalling egs |
Wnts, TGF beta, FGF, hedgehog, neurotrophins |
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Juxtacrine signalling |
direct contact - eg Notch |
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Permissive induction |
cell already specified, signal supports development - |
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cell obtains positional info by |
morphogen gradient |
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"generative" (to describe development) |
each step built on the previous one |
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Ontogeny recapitulates phylogeny |
(animals more alike in embryonic stages than in adulthood) |
