Katzung Pharm

Front 1

Diuretic group that acts predominantly in the proximal tubule

Back 1

Carbonic Anhydrase inhibitors

Front 2

MOA Carbonic Anhydrase inhibitors

Back 2

Block NaHCO3 reabsorption

Front 3

site of loop diuretic action

Back 3

Thick ascending limb (Loop of Henle)

Front 4

Inhibition of salt transport by loop diuretics may cause loss of...

Back 4

Divalent cations (Mg2+ and Ca2+)

Front 5

Contraindications of carbonic anhydrase inhibitors

Back 5

Patients with Cirrhosis

Front 6

Reduction in the secretion of loop diuretics may be a result of...

Back 6

Administration of NSAIDS or Probenecid, which compete for weak acid secretion in the proximal tubule.

Front 7

MOA of loop diuretics

Back 7

Inhibit the luminal Na+/K+/2Cl- transporter

Front 8

Loop diuretics induce renal prostaglandin synthesis

Back 8

NSAIDS (indomethacin) can interfere with the actions of the loop diuretics (especially in those with Nephrotic syndrome or hepatic cirrhosis)

Front 9

Vascular effects of Furosemide and Ehacrynic acid

Back 9

Reduce pulmonary congestion and left ventricular filling pressures in heart failure (Furosemide increases renal blood flow)

Front 10

Indications for loop diuretics

Back 10

acute pulmonary edema, acute hypercalcemia,hyperkalemia, acute renal failure and anion disease

Front 11

Toxicity of loop diuretics

Back 11

Hypokalemic metabolic acidosis, ototoxicity (usually reversible), hyperuricemia, hypomagnesemia, Allergic reactions, SEVERE dehydration.

Front 12

Site of action for Thiazide diuretics

Back 12

Distal convoluted tubule

Front 13

Only parenteral thiazide

Back 13

Chlorothiazide

Front 14

MOA of Thiazide diuretics

Back 14

Blocking the Na+/Cl- transporter

Front 15

In contrast to loop diuretics, thiazides actually enhance....

Back 15

Ca2+ reabsorption in the Distal convoluted tubule

Front 16

Major indications for thiazide diuretics

Back 16

Hypertension, heart failure, nephrolithiasis due to idiopathic hypercalciuria, nephrogenic diabetes insipidius

Front 17

Toxicity of Thiazides

Back 17

Hypokalemic metabolic acidosis, Impaired carbohydrate tolerance, Hyperlipidemia, hyponatremia, allergic rxn

Front 18

Excessive use of any diuretic is dangerous in...

Back 18

hepatic cirrhosis, borderline renal failure, or heart failure

Front 19

Triamterene and amiloride do not block the aldosterone recpetor, but

Back 19

directly interfere with Na+ entry through the ion channels in the apical membrane

Front 20

Toxicity of potassium sparing diuretics

Back 20

Hyperkalemia, Hyperchloremic metabolic acidosis, Gynecomastia, (BPH with spironolactone)

Front 21

Diuretic induced renal failure

Back 21

Triamterene with indomethacin has induced ARF

Front 22

Treatment of nephrolithiasis

Back 22

Thiazide diuretic