Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

22 Cards in this Set

  • Front
  • Back
Diuretic group that acts predominantly in the proximal tubule
Carbonic Anhydrase inhibitors
MOA Carbonic Anhydrase inhibitors
Block NaHCO3 reabsorption
site of loop diuretic action
Thick ascending limb (Loop of Henle)
Inhibition of salt transport by loop diuretics may cause loss of...
Divalent cations (Mg2+ and Ca2+)
Contraindications of carbonic anhydrase inhibitors
Patients with Cirrhosis
Reduction in the secretion of loop diuretics may be a result of...
Administration of NSAIDS or Probenecid, which compete for weak acid secretion in the proximal tubule.
MOA of loop diuretics
Inhibit the luminal Na+/K+/2Cl- transporter
Loop diuretics induce renal prostaglandin synthesis
NSAIDS (indomethacin) can interfere with the actions of the loop diuretics (especially in those with Nephrotic syndrome or hepatic cirrhosis)
Vascular effects of Furosemide and Ehacrynic acid
Reduce pulmonary congestion and left ventricular filling pressures in heart failure (Furosemide increases renal blood flow)
Indications for loop diuretics
acute pulmonary edema, acute hypercalcemia,hyperkalemia, acute renal failure and anion disease
Toxicity of loop diuretics
Hypokalemic metabolic acidosis, ototoxicity (usually reversible), hyperuricemia, hypomagnesemia, Allergic reactions, SEVERE dehydration.
Site of action for Thiazide diuretics
Distal convoluted tubule
Only parenteral thiazide
MOA of Thiazide diuretics
Blocking the Na+/Cl- transporter
In contrast to loop diuretics, thiazides actually enhance....
Ca2+ reabsorption in the Distal convoluted tubule
Major indications for thiazide diuretics
Hypertension, heart failure, nephrolithiasis due to idiopathic hypercalciuria, nephrogenic diabetes insipidius
Toxicity of Thiazides
Hypokalemic metabolic acidosis, Impaired carbohydrate tolerance, Hyperlipidemia, hyponatremia, allergic rxn
Excessive use of any diuretic is dangerous in...
hepatic cirrhosis, borderline renal failure, or heart failure
Triamterene and amiloride do not block the aldosterone recpetor, but
directly interfere with Na+ entry through the ion channels in the apical membrane
Toxicity of potassium sparing diuretics
Hyperkalemia, Hyperchloremic metabolic acidosis, Gynecomastia, (BPH with spironolactone)
Diuretic induced renal failure
Triamterene with indomethacin has induced ARF
Treatment of nephrolithiasis
Thiazide diuretic