Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
markers for endothelial cells
|
1. factor 8 related antigen
2. HLA-DR 3. Von Willebrand factor 4. lectin Ulex europaeus agglutinin 1 |
|
|
two monoclonal abs in KS
|
EN4 and PAL E
implies KS derived from endothelium of lymphatic origin |
|
|
KS spindle cells +
|
CD34 ag
Ulex europaeus agglutinin 1 CD34 is a glycoprotein expresed by endotheial cells of small bv (not of lymphatic origin) |
|
|
sensitive marker of KS
|
VEGFR-3
partial lymphatic endothelial differentiation does not distinguis KS from other angiosacrcomas |
|
|
evaluate problematic vascular proliferations wtih immunohistochemistry?
|
LANA (latency-associated nuclear ag) expression
not HHV-8 PCR |
|
|
AIDS-KS progressive regression
|
spindle cell proliferation
expression of HHV-8 latency genes LNA-1 and cyclin-D1 |
|
|
HHV-8 latency genes
|
LNA-1
Cyclin-D1 |
|
|
AIDS-KS regression
|
reduction or loss of dermal spindle cells
decrease latent nuclear antigen-1 (LNA-1) and cyclin-D1 immunoreactivity NO CHANGE IN BCL-2 EXPRESSION |
|
|
VEGFR-3
|
tyrosine kinase receptor expressed almost exclusively by lymphatic endothelial cells in adults
|
|
|
tx KS
|
1. surgery
2. Laser 3. Radiotx (electron good only to dermis) 4. chemo intralesional or systemic(vinblastine and bleomycin) |
|
|
vinblastine
|
vinca alkaloid from flowering plant periwinkle vinca rosea
leukopenia and immunosupression tx KS intralesional IV with IM bleomycin |
|
|
bleomycin
|
glycopeptide antibiotic produced by bacterium strepomyces verticillus
KS tx with doxorubicin and vincristine or vinblastine |
|
|
vincristine
|
leurocristine
vinca alkaloid KS tx with vinblastine or doxorubicin adn bleomycin |
|
|
sirolimus
|
VEGF inhibitor
tx and possible prevention of KS new immunosupressive agent transplant pts inhibit KS progression |
|
|
matrix metalloproteinase-2 inhibitors
|
tetracycline analogues without antibiotic activity
chemically modified tetracycline green tea flavonids IL-12 and IL4 receptor directed cytotoxin cartilage extracts KS tx for endothelin-1 receptors, KSHV G-protein coupled recetpros, and angiopoietin-2 tx targets? |
|
|
iatrogenic KS tx
|
DC immunosupressive
cs and cytotoxic drugs dc partial or complete regression of KS |
|
|
VEGF type 2 receptor inhibitor (SU5416)
|
synthetic low mocecular weight compound
KS tx? |
|
|
hCG tx ks?
|
intralesional or systemic
limited side effects men > wome female hormone protective KS? |
|
|
thalidomide KS?
|
inhibits agniogenesis and development of new blood vessels in KS
toxicity drowsiness and depression |
