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11 Cards in this Set
- Front
- Back
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Gram negatives use what to adhere to cell surfaces
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Pili/Fimbrae
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Gram positives use what to adhere to cell surfaces
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Teichoic acids
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What infects catheters and prosthetics
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Staph epidermidis
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Causes plaque and dental carries
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Streptococcus mutans
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Intracellular organisms elicit what type of immune response
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Cell mediate immunity
Granuloma formation |
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Invasins
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surface proteins that allow an organism to bind to and invade normally NON-phagocytic human cells
escapes immune system |
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Endotoxin
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LPS is part of gram negative outer membrane
toxic portion it lipid A -generally not release until death of cell LPS is heat stable -cannot be converted to toxoid |
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Mechanism of Endotoxin
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LPS activates macrophages
-leads to release of TNF-alpha, IL-1 and IL-6 IL-1 --> fever Macrophage activation and products --> tissue damage Bradkinin induced vasodilation --> shock Coagulation (DIC) is mediated through the activation of Hageman Factor |
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Exotoxin
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Protein toxin
Secreted by bacterial cells Can be modified to produce a toxoid, that is immunogenic but no longer toxic (vaccines) |
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A-B component protein toxins
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B --> binds to specific cell receptors to facilitate internalization of A
A--> active (toxic) component |
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What can look like endotoxin shock?
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Superantigens
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