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14 Cards in this Set
- Front
- Back
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JAMA article, inflammatory biomarkers associated with increased risk of COPD exacerbation
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WBC CRP fibrinogen
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What is the asthma susceptibility locus?
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Chromosome 17q21, three genes encoded ORM-like 3 (ORMDL3), gasdermin B (GSDMB) and zona pellucid a-binding protein (ZPBP2)
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Function of ORMDL3 protein
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Suppresses the palmitoyl-co-A transferase or SPT which is the rate-limiting enzyme of sphingomyelin, linked to airway hyperreactivity
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What is cystatin?
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A protein secreted by almost all uncleared cells, freely filtered by glomeruli, not excreted in urine but metabolized by prox tubule - does not need timed collections
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When is cystatin C measurements indicated?
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EGFR 45-60 but no other manifestations of CKD or EGFR 60-74, no CKD but has risk s.a. HTN, DM or heart failure
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Scrotal nodules in a patient with normal calcium, phosphorus and PTH levels
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Idiopathic scrotal calcinosis
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Parasite responsible for Chagas' disease
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T. cruzi
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Hallmarks of chronic Chagas' disease
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Cardiomyopathy, mega esophagus and megacolon
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First line treatment of Chagas' disease
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Benznidazole x 60 days
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Which part of the cardiac wall is affected usually by Chagas' disease?
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Posterolateral wall of left ventricle
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what is goserelin acetate
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drug that suppresses endogenous testosterone and estradiol
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Effects of androgen deficiency and estrogen deficiency
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androgen deficiency causes decreased muscle size and strength; estrogen deficiency causes increased body fat; both contributes to decline in sexual function
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what is anastrozole?
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drug that suppresses conversion of testosterone to estradiol
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What is the brand name of anastrozole?
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Arimidex
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