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92 Cards in this Set
- Front
- Back
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What do the follicles of LN contain?
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B cells, primary--dense and dormant, secondary--pale and active
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What does the medulla contain?
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medullary cords and sinuses
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What do the medullary sinuses contain?
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reticular cells and MG
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Where is the paracortex?
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between the follicles and the medulla
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What is in the paracortex?
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T cells
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Which part of the LN is not well developed in DiGeorges Syndrome?
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the paracortex
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What does the right thoracic duct drain?
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r arm and r face
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Where are the T cells in the spleen?
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PALS, red pulp
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Where are the B cells in the spleen?
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white pulp follicles
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What is derived from the 3rd brachial pouch?
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thymus
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What is the orgin of lymphocytes?
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mesenchyme
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What is found in the cortex of the thymus?
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immature T cells
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What is found in the medulla of the thymus?
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mature T cells, epithelial reticular cells, hassall's corpuscle
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Where does positive and negative T cell selection happen?
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corticomedullary junction of the thymus
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Which cells are found in innate immunity?
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neutrophils, MG, dendritic cells, complement
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What cells are in adaptive immunity?
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T, B cells, circulating Ab
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What do Th1 cells do?
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secrete IL-2 and INF-g to activated MGs and CD8 cells
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What do Th2 cells do?
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make IL-4, IL-5 to help B cells make Ab
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What are CD8 cells responsible for?
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cytotoxic effect
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What cells express MHC-I?
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almost all nucleated cells
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Where is the Ag loaded onto MHCI?
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RER
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Which MHC pairs iwth Beta2-microglobulin?
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MHC1
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Where is the Ag loaded onto MHCII?
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acidified endosome
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Which MHC is responsible for organ rejection?
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MHCII
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What hypersensitivity response happens with IgE?
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type I
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What type of hypersensitivity response involves T cells?
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type IV
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What are the Ag presenting cells?
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B cell, MG, dendritic cell
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Which chains contribute to Fab?
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heavy and light
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Which chains contribute to Fc?
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heavy only
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What do Ab do?
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neutralize, opsonize, and complement activation
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How is Ab diveristy generated?
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random recombination of VJ and VDJ, recomdination of heavy with lights, somatic hypermutation, addition of nucleotides to DNA during recomination by terminal deoxynucleotidyl transferase
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Which Ab isotypes are expressed on the surface of mature B cells?
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IgM and IgD
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What causes isotype switching?
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cytokines and CD40L
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Which isotypes fix complement?
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IgG and IgM
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Which isotype crosses the placenta?
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IgG
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What stimulates MG?
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INF-gamma
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What cells have CD4, TCR, CD3, CD28, CD40L?
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Helper T cells
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What cells have CD8,TCR, CD3?
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Cytotoxic T cells
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What cells have IgM, B7, CD19, CD20, MHCII?
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B cells
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What cells have MHC II, CD14, FcR, C3bR?
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MG
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What cells have MHC I?
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all cells except mature red cells
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What is the function of C5a?
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neutrophil chemotaxis
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What does a C1 esterase I deficiency lead to?
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hereditary angioedema
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What does a deficiency in C3 lead to?
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severe reccurent pyogenic sinus and respiratory tract infection
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What does a C6-C8 deficiency lead to?
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Neisseria bacteremia
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What does a defciency of decay-accelerating factor lead to?
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paroxysmal nocturnal hemoglobinuria PNH
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What do interferons do?
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put uninfected cells into an antiviral state
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What do interferon alpha and beta do?
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inhibit viral ptn synthesis
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What does interferon gamma do?
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inc MHCI and MHCII expression and Ag presentation in all cells
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Which infections require passive immunity?
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Tetanus, Botulinum, HBV, Rabes--To be healed rapidly
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What is anergy?
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when self-reactive T cells become nonreactive without a costimulatory molecule
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What are the two types of Type I hypersensitivity?
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anaphylaxis and atopic (hay fever)
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Why is Type I hypersensitivity so fast?
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because the cels are presensitized and the IgE is ready and awaiting the arrival of another exposure
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What are the types of Type III hypersensitivity?
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immune complex, serum sickness, arthus reaction
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What are examples of type II hypersensitivity?
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hemolytic anemeia, HTP, erthroblastosis fetalis, RF, Goodpasture, bullous pemphigoid, grave's dz, MG
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What are examples of Type III reaction?
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Lupus, RA, PAN, Post-strep glomerulonephritis, serum sickness, arthus, hypersensitivity pnumonitis
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What are examples of Type IV reaction?
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Type I DM, MS, GBS, Hashimoto's, GVH dz, PPD, Contact dermitis
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What does a pt with ANA have?
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SLE
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What does a pt with Anti-dsDNA and anti-smith have?
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SLE
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What does a patient with antihistone have?
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Drug induced lupus
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What does a patient iwth Anti-IgG RF have?
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RA
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What does a pt with cANCA or pANCA have?
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vasculitis
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What does a pt with anticentromere have?
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CREST, scleorderma
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What does a pt with anti-Scl-170 have?
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diffuse scleroderma
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What does a pt with antimitochondrial Ab have?
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primary biliary cirrhosis
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What does a pt with antigliadin have?
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celiac dz
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What does a pt with anti-BM have?
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goodpastures syndrome
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Whta does a pt with anti-epithelial cells have?
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pemphigus vulgaris
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What does a pt with antimicrosomal have?
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hashimoto's thyroiditis
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What does a pt with Anti-Jo-1 have?
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polymyositis, dermatomyositis
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What do pt with B27 HLA have?
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PAIR, Psoriasis, ankylosing spondylitis, IBD, Reiter's syndrome
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What does a pt with B8 HLA have?
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Grave's Dz, celiac sprue
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What does a pt with DR2 have?
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MS, hay fever, SLE, goodpasture
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What does a pt with DR3 have?
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DMI
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What does a pt with DR4 have?
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RA, DMI
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What does a pt with DR5 have?
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pernious anemia, Vit B12 deficiency, Hashimoto's
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What does a pt with DR7 have?
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steroid responsive nephrotic syndrome
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Why does Hyperacute tissue rejection happen?
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preformed Ab to donor tissue
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When does acute rejection happen?
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within weeks
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How does acute rejection happen?
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cytotoxic T cells react with foreign MHC
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What is chronic rejection?
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Ab-mediated vascular damage, months to years, irreversible
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What is GVH dz?
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grafted immunocompetent T cells proliferate in irradiated IC host, organ dysfunction
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What are the signs of GVH dz?
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maculopapular rash, jaundice, HSM, D
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What condition presents with disseminated mycobacterial infection?
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IL-12 receptor deficincy
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Which condition presents with recurrent pyogenic infections, thrombocytopenic purpura, eczema?
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Wiskott-Aldrich
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Which condition has high levels of IgE?
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Job's syndrome
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Which condition has high levels of IgA, nl levels of IgE, low IgM?
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Wiskott-Aldrich
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Which condition has high levels of IgM, very low levels of IgG, IgA, and IgE?
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hyperIgM syndrome
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Which condition presents early with severe pyogenic and fungal infection and delayed separation of umbilicus?
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Leukocyte adhesion deficiency syndrome
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Which condition is diagnosed with nitroblu tetrazolium dye reduction test?
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chronic granulomatous disease
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Which condition presents with sinus and lung infections, milk allergies, and D?
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selective immunoglobulin deficiency
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Which Ig is the most common selective Ig deficiency?
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IgA
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