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30 Cards in this Set
- Front
- Back
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83. 9 oncogenes?
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1. abl
2. c-myc 3. L-myc 4. N-myc 5. bcl-2 6. erb-B2 7. ras 8. ret 9. c-kit |
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84. 10 Tumour suppressor genes?
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1. Rb (13q)
2. p53 (17p) 3. BRCA1 (17q)/BRCA2 (13q) 4. p16 (9p) 5. APC (5q) 6. WT1 (11P) 7. NF1 (17q)/ NF2 (22q) 8. DPC (18q) 9. DCC (18q) |
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85. abl associated tumour and gene product?
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a. CML
b. Tyrosine kinase c. Oncogene |
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86. c-myc associated tumour and gene product?
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a. Burkitt’s lymphoma
b. Transcription factor |
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87. bcl-2 associated tumour and gene product?
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a. Follicular lymphoma and undifferentiated lymphomas (inhibits apoptosis)
b. Anti-apoptotic molecule. |
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88. erb-B2 associated tumour and gene product?
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a. Breast, ovarian, and gastric carcinomas.
b. Tyrosine kinase |
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89. ras associated tumour and gene product?
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a. Colon carcinoma
b. Gene product = GTPase |
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90. L-myc associated tumour and gene product?
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a. Lung tumour
b. Transcription factor |
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91. N-myc associated tumour and gene product?
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a. Neuroblastoma
b. Transcription factor |
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92. ret associated tumour and gene product?
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a. MEN II and III
b. Tyrosine Kinase |
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93. c-kit associated tumour and gene product?
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a. Gastrointestinal stromal tumour (GIST)
b. Cytokine receptor |
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94. What do mutations in the above Oncogenes cause?
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a. Gain of function mutation.
b. Need damage to only 1 allele. |
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95. What do mutations to Tumour suppressor genes cause?
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a. Loss of function mutation.
b. Both alleles must be lost for expression of disease. |
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96. Rb (13q) associated tumours and gene product?
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a. Retinoblastoma and osteosarcoma
b. Rb gene product blocks G1-> S phase of the cell cycle. |
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97. p53 (17p) associated tumour and gene product?
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a. Most human cancer, Li-Fraumeni syndrome
b. P53 gene product blocks G1 -> S phase of the cell cycle. |
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98. BRCA1 (17q) associated tumour and gene product?
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a. Breast and Ovarian cancer.
b. Encodes DNA repair protein |
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99. BRCA2 (13q) associated tumour and gene product?
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a. Breast cancer
b. DNA repair protein |
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100. p16 (9p) associated tumour?
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a. Melanoma
b. Note p53 and p16 (and WT1-11p)are the only tumour suppressor genes located on the short arm “p” of a chromosome. Pp. Makes sense. |
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101. APC (5q) associated tumour?
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a. Colorectal cancer (associated w/FAP).
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102. WT1 (11p) associated tumour?
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a. Wilm’s tumour
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103. NF1 (17q) associated tumour?
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a. Neurofibromatosis type 1.
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104. NF2 (22q) associated tumour?
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a. Neurofibromatosis type 2.
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105. DPC (18q) associated tumour?
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a. Pancreatic cancer.
b. “DPC –Deleted in Pancreatic Cancer” |
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106. DCC (18q) associated tumour?
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a. Colon cancer “DCC- Deleted in Colon Cancer”.
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107. PSA elevated in?
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a. Prostate carcinoma, BPH, prostatitis.
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108. Prostatic acid phosphatase?
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a. Prostate carcinoma.
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109. CEA?
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a. Carcinoembryonic antigen.
b. Very nonspecific but produced by ~70% of colorectal and pancreatic cancers. c. Also produced by gastric, breast, and thyroid medullary carcinomas. |
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110. α-fetoprotein?
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a. Normally made by fetus.
b. Hepatocellular carcinomas c. Non-seminomatous germ cell tumours of the testis (e.g., yolk sac tumour) |
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111. β-hCG (3 cancers)?
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a. Hydatiform moles
b. Choriocarcinoma c. Gestational trophoblastic tumours d. “HCG” |
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112. CA-125 (2 cancers)?
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a. Ovarian and malignant epithelial tumours
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