Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
145. Erythema nodosum- With what 6 conditions is it associated?!?
|
a. Inflammatory lesions of subq fat, usually on anterior shins.
b. Associated w/coccidioidomycosis, histoplasmosis, TB, leprosy, strep infections, sarcoidosis. |
|
|
146. Pityriasis rosea?
|
a. Herald patch followed days later by “Christmas tree” distribution.
b. Multiple papular eruptions; remits spontaneously. |
|
|
147. Strawberry hemangioma?
|
a. First few weeks of life (1/200 births)
b. Grows rapidly and regresses spontaneously at 5-8 yrs of age. |
|
|
148. Cherry hemangioma?
|
a. Appears in 30s-40s. Does not regress.
|
|
|
149. Squamous Cell carcinoma of skin?
|
a. Very common.
b. Associated w/excessive exposure to sunlight and arsenic. c. Commonly appear on hands and face. d. Ulcerative red lesion. Associated w /chronic draining sinuses. |
|
|
150. Growth of Squamous cell carcinoma of skin?
|
a. Locally invasive but rarely met.
|
|
|
151. Histopathology of Squamous cell carcinoma?
|
a. Keratin “pearls”.
|
|
|
152. Precursors lesion to squamous cell carcinoma!?!?
|
a. Actinic keratosis.
|
|
|
153. Keratoacanthoma?
|
a. Actinic keratotic variant that grows rapidly (4-6 wks) and regresses spontaneously (4-8) wks.
|
|
|
154. Basal cell carcinoma?
|
a. Most common in sun-exposed areas of body.
b. Locally invasive, but almost never mets. |
|
|
155. Appearance of Basal cell carcinoma?
|
a. Rolled edges w/central ulceration.
b. Gross pathology: pearly papules, commonly w/telangiectasias. |
|
|
156. Nuclei of Basal cell carcinomas?
|
a. Basal cell tumours have “Palisading nuclei”.
|
|
|
157. Melanoma?
|
a. Common tumour w/significant risk of metastasis.
b. S-100 tumour marker. Think of SPF-100. c. Associated w/sunlight, fair-skinned persons at ↑ risk. d. Dark w/irregular borders. |
|
|
158. What correlates w/risk of mets in Melanoma!??!?!?!?
|
a. DEPTH of tumor.
|
|
|
159. Precursor to melanoma?
|
a. Dysplastic nevus (atypical mole).
|
|
|
160. What does the lipoxygenase pathway yield?
|
a. Leukotrienes.
|
|
|
161. LTB4?
|
a. Neutrophil chemotactic agent.
|
|
|
162. LTC4, D4, and E4?
|
a. Function in bronchoconstriction, vasoconstriction, contraction of smooth muscle, and ↑ vascular permeability.
|
|
|
163. PGI2?
|
a. Inhibits platelet aggregation and promotes vasodilation.
b. My own note: The problem with COX2 inhibitors is that they also inhibit PGI2 (prostacyclin). |
|
|
164. Action of Phospholipase A2 and what inhibits it?
|
a. Converts membrane lipids (e.g. phosphatidylinositol) to arachidonic acid.
b. Arachidonic acid can than either go through the lipoxygenase pathway to produce HPETEs (hydroperoxides) and leukotrienes or it can enter the cox pathway. c. Corticosteroids inhibit phospholipase A2 so they inhibit both pathways. d. Corticosteroids also inhibit the protein synthesis caused by cox-2 so triple wammy). |
