Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
59. What hormones act through cAMP (FLAT CHAMP)?
|
1. FSH
2. LH 3. ACTH 4. TSH 5. CRH 6. hCG 7. ADH (V2 receptor) 8. MSH 9. PTH 10. Calcitonin 11. GHRH 12. Glucagon. b. Prob better off memorizing whats not on this list. |
|
|
60. What hormones work through cGMP?
|
1. ANP
2. NO (EDRF-endothelium derived relaxing factor) b. “think vasodilators” |
|
|
61. What 4 hormones work through IP3?
|
1. GnRH
2. Oxytocin 3. ADH (V1 receptor) 4. TRH b. “GOAT” |
|
|
62. Cytosolic steroid receptors?
|
1. Vitamin D
2. Oestrogen 3. Testosterone 4. Cortisol 5. Aldosterone 6. Progesterone b. “VET CAP” |
|
|
63. Nuclear hormone receptors?
|
a. T3/T4.
|
|
|
64. Intrinsic tyrosine kinase receptors (MAP kinase pathway)?
|
1. Insulin
2. IGF-1 3. FGF 4. PDGF b. Think growth factors |
|
|
65. Receptor-associated tyrosine kinase (JAK/STAT pathway) hormones?
|
a. GH and Prolactin the 2 eosinophiles.
b. Also IL-2. |
|
|
66. Effect of ↑ levels of sex hormone-binding globulin (SHBG) in men?
|
a. Lowers free testosterone (gynecomastia).
|
|
|
67. Effect of ↓ (not ↑) SHBG?
|
a. Raises free testosterone -> hirsutism.
|
|
|
68. Solubility and action of steroid hormones?
|
a. Steroid hormones are lipophilic and relatively insoluble in plasma.
b. Therefore, they must circulate bound to specific binding globulins, which ↑ solubility and allow for ↑ delivery of steroid to the target organ. c. The need for gene transcription and protein synthesis delays the onset of action of these hormones. |
|
|
69. Where is most T3 formed?
|
a. In blood.
|
|
|
70. What cells produce T4 and T3 in thyroid?
|
a. Follicles of thyroid.
|
|
|
71. 5 functions of thyroid hormones?
|
1. Bone growth (synergism with GH)
2. CNS maturation- Think of retarded cretins. 3. ↑ β1 receptors in heart = ↑ CO, HR, SV, contractility. 4. ↑ BMR via ↑ Na/K-ATPase activity = ↑ O2 consumption, RR, body temp. 5. Energy-effects in next question |
|
|
72. Effect of thyroid hormones are carbs and fat?
|
a. ↑ Glycogenolysis
b. ↑Gluconeogenesis c. ↑ lipolysis. |
|
|
73. What is T3/T4 bound to mostly in blood and what are the implications?
|
a. Thyroxine-binding globulin.
b. Only free hormone is active |
|
|
74. When is TBG ↓?
|
a. In hepatic failure so T3/T4 would be ↑
|
|
|
75. When is TBG ↑ in women?
|
a. In pregnancy or OCP use (oestrogen ↑ TBG).
|
|
|
76. Which binds to receptor w/greater affinity T3 or T4?
|
a. T3.
|
