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9 Cards in this Set
- Front
- Back
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the T-cell maturation/ontogeny is antigen...
the T-cell differentiation into effector memory T cell is antigen... |
independent
dependent |
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location of T cell ontogeny and differentiation
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ontogeny-bone marrow
differentiation - thymus |
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as T cells differentiate in thymus
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gene rearrangement of the T cell antigen-receptor (TCR) genes and expression of either CD4 or CD8 proteins
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what genes encode the light chain?
heavy chain? |
light chain- alpha;IGL
heavy chain- beta;IGH, with beta occuring first |
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list the time order in which beta genes (VH, C) of T cells are rearranged
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DJ, VDJ, VDJC
this sequence encodes the TCR beta chain |
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in what order are the light chain alpha genes rearranged?
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VJ then VJC, encoding TCR alpha chain
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during t cell maturation
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the thymocyte is also arranging its CD3,CD4, and CD8 genes in order to transcribe and express these cell-surface molecules. At this stage of thymocyte maturation, CD4- and CD8- are not yet expressed and these thymocytes are called “double negatives”.
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the antigen independent and dependent phases of B cells
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antigen independent phase- b cell maturation/ontogeny
antigen dependent phase - b cell differentiation into memory and plasma cells |
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explain antigen independent phase of b cells
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hematopoetic stem cell stage (HSC) in the bone marrow -> blast cell formation-> (a cell preparing for cell division/proliferation)-> pro-B cell-> pre-B cell->immature B cell->mature B cell
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