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17 Cards in this Set
- Front
- Back
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Muscular rigidity + fever + Autonomic instability + Change in mental status + Elevated CK
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Neuroleptic malignant syndrome
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Treatment for NMS:
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First discontinue offending agent, then use supportive measures (hydration, antipyretics), and occasional use of bromocriptine or dantrolene
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Dysphoric state characterized by subjective desire to be in constant motion.
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Akathisia
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Treatment for akathisia
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Anticholinergics and beta blockers
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The propensity of a drug to cause a Parkinson-like picture is related to its ____ blocking activity.
Be specific! |
D-2 blocking activity
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Side effects of Levodopa/Carbidopa:
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Anorexia, nausea, psychosis, hallucinations, orthostatic hypotension, dyskinesia
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What class of medicine is trihexyphenidyl?
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Anticholinergic
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What class of medicine is benzotropine?
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Anticholinergice
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What class of medicine is bromocriptine?
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Dopamine agonist
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What are the side effects of dopamine agonists?
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Nausea, orthostatic hypotension, psychosis, dyskinesia
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What class of medicine is pergolide?
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Dopamine agonist
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What class of medicine is Pramipexole?
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Dopamine agonist
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What class of medicine is Ropinerole?
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Dopamine agonist
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Name 2 COMT inhibitors?
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Tolcapone and Entacapone
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What are some side effects of COMT inhibitors
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Nausea, vomiting, insomnia, orthostatic hypotension, confusion, dyskenesia
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Suppose you start a new-onset parkinon patient on Levodopa/Carbidopa and find minimal response. Next step?
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Increase dose
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How to treat Dyskinesia side effects?
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1. Reduce dose of Levodopa
2. Add dose of dopamine agonist 3. Discontinue selegiline 4. Add amantadine 5. Consider surgery |
