Iv Induction Agents

Front 1

etomidate

pKa
protein binding

Back 1

4.2
75

Front 2

propofol

pKa
protein binding

Back 2

11
98

Front 3

STP

pKa
protein binding

Back 3

7.6
80

Front 4

methohexital

pKa
protein binding

Back 4

7.9
85

Front 5

Ketamine

pKa
protein binding

Back 5

7.5
12

Front 6

what is the only drug without metabolites?

Back 6

ketamine

Front 7

which drug has biggest drop in blood pressure

Back 7

propofol

Front 8

biggest increase heart rate

Back 8

ketamine

Front 9

does thiopental increase or decrease rate?

Back 9

increase

Front 10

which enzyme is affected in acute intermittent porphyria

Back 10

prophobilogen deaminase

Front 11

which two agents are not water soluble

Back 11

propofol
etomidate

Front 12

which isomer is more potent in the barbiturates, S(-) or R(+)?

Back 12

S (1)

Front 13

% barbs non-ionized at pH 7.4

Back 13

61%

Front 14

thiopental is _______% protein bound

Back 14

80%

Front 15

the methohexital molecule substitues a __________ group for a ________ group

Back 15

methyl CH3
sulfur

Front 16

competitive drugs that bind versus barbs

Back 16

ASA
indomethacin
naproxen
coumadin

Front 17

which morbidities lead to decreased plasma proteins (albumin) for protein binding

Back 17

uremic
hepatic dz
3rd trimester pregnancy

Front 18

actual dose STP ~ 350

10% decrease protein changes ED to ________

20% decrease protein changes ED to _________

Back 18

105

140

Front 19

never give ketamine to what type of patient

Back 19

head injury

Front 20

barbs MOA

Back 20

RAS

Front 21

which structures are included in the RAS control loop?

Back 21

brainstem, thalamus, cortex

Front 22

how are EPSPs affected with barbs?

IPSPs?

Back 22

fewer

unaltered or enhanced

Front 23

is GABA exitatory or inhibitory?

Back 23

main inhibatory

Front 24

which does GABA mediate? postsynaptic or presynaptic?

Back 24

both - 20-40% all synapses

Front 25

which ion do barbs affect in GABA

Back 25

dependent chloride channel

Front 26

which other ion(s) are affected in the MOA of barbs
Na? Ca? K? Mag?

Back 26

K and Ca

Front 27

will you find hypokalemia or hyperkalemia with a patient in a thiopentone coma?

Back 27

both. severe hypokalemia refractory to K therapy may occur during coma. Severe rebound may occur after cessation

Front 28

barbs:
increase duration of Cl channel opening, or increase frequency of opening

Back 28

increase the duration

Front 29

which induction agent increases frequency of opeing of GABA Cl channel?

Back 29

benzo

Front 30

true or false

barbs have a direct effect on Na channels?

Back 30

true

Front 31

which two agents are not water soluble

Back 31

propofol
etomidate

Front 32

which isomer is more potent in the barbiturates, S(-) or R(+)?

Back 32

S (1)

Front 33

% barbs non-ionized at pH 7.4

Back 33

61%

Front 34

thiopental is _______% protein bound

Back 34

80%

Front 35

the methohexital molecule substitues a __________ group for a ________ group

Back 35

methyl CH3
sulfur

Front 36

competitive drugs that bind versus barbs

Back 36

ASA
indomethacin
naproxen
coumadin

Front 37

which morbidities lead to decreased plasma proteins (albumin) for protein binding

Back 37

uremic
hepatic dz
3rd trimester pregnancy

Front 38

actual dose STP ~ 350

10% decrease protein changes ED to ________

20% decrease protein changes ED to _________

Back 38

105

140

Front 39

never give ketamine to what type of patient

Back 39

head injury

Front 40

barbs MOA

Back 40

RAS

Front 41

which two agents are not water soluble

Back 41

propofol
etomidate

Front 42

which isomer is more potent in the barbiturates, S(-) or R(+)?

Back 42

S (1)

Front 43

% barbs non-ionized at pH 7.4

Back 43

61%

Front 44

thiopental is _______% protein bound

Back 44

80%

Front 45

the methohexital molecule substitues a __________ group for a ________ group

Back 45

methyl CH3
sulfur

Front 46

competitive drugs that bind versus barbs

Back 46

ASA
indomethacin
naproxen
coumadin

Front 47

which morbidities lead to decreased plasma proteins (albumin) for protein binding

Back 47

uremic
hepatic dz
3rd trimester pregnancy

Front 48

actual dose STP ~ 350

10% decrease protein changes ED to ________

20% decrease protein changes ED to _________

Back 48

105

140

Front 49

never give ketamine to what type of patient

Back 49

head injury

Front 50

barbs MOA

Back 50

RAS

Front 51

should you give etomidate to ICU patients? if not, why not?

Back 51

should not - inhibits the enzyme 11beta-hydroxylase -> which decreases cortisol/aldosterone = decreased ability to recover from stress, surgery

Front 52

which structures are involved in the control loop of the RAS?

Back 52

brain stem, thalamus, cortex

Front 53

excitatory neurotransmission are ___________ (EPSPs)
and inhibitory transmission are _____________ (IPSPs)

Back 53

depressed/fewer

unaltered or enhanced (same or more)

Front 54

true or false?

barbs affect the dependent Ca channels in the brain

Back 54

false- mainly chloride, but also

affect K and Na channels

Front 55

GABA mediates
a) post synaptic
b) presynaptic
c) neither
d) both

Back 55

d) both
main INHIBITORY neurotransmitter (20-40% all synapses)

Front 56

will a patient develop hyperkalemia or hypokalemia secondary to thiopentone coma?

Back 56

both... first refractory hypo; then severe rebound hyperkalemia

Front 57

GABAa receptors sited in a complex which includes specific interaction sites for:
a) benzo
b) barbs
c) steroid anesthetic agents
d) alcohol
e) all of the above

Back 57

e) all of the above

Front 58

for barbs to work, they must be
a) unbound
b) unionized
c) both a and b

Back 58

c) both a and b

Front 59

barbs increase duration/frequency of channel opening, and benzos increase duration/frequency of channel opening

Back 59

barbs = duration

benzo = frequency

Front 60

true or false?
barbs can reduce voltage-dependent activation of Na channels

Back 60

true

Front 61

barbs induce/inhibit hepatic enzymes

Back 61

induce

Front 62

thiopental increases/decreases heart rate?

Back 62

transiently increases 10-20 reflexive secondary to 10-20 drop in b/p

Front 63

dose STP

Back 63

3-5mg/kg

Front 64

thiopental EEG may correspond to which guedel's stage of anesthesia

Back 64

2nd stage

Front 65

thiopental increases or decreases:
ICP
CMRO2
CBF

Back 65

all decrease

Front 66

thiopental shows low voltage EEG wave form which correlates to which wave?

Back 66

delta

Front 67

which of the following have histamine release?
propofol, thiopental, etomidate, ketamine?

Back 67

propofol and thiopental

Front 68

which has the most possibility of allergic reaction?

Back 68

methohexital