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87 Cards in this Set
- Front
- Back
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Induction dose (mg/kg IV)
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Propofol: 1.0 – 2.5
thiopental: 3-5 methohexital: 1.0 – 1.5 midazolam: 0.1 – 0.3 diazepam: 0.3 – 0.6 lorazepam: 0.03 – 0.1 ketamine: 1.0 – 2.0 etomidate: 0.2 – 0.3 dexmedetomidine: N/A |
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Duration of action (min)
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Propofol: 3.0 – 8.0
thiopental: 5.0 – 10.0 methohexital: 4-7 midazolam: 15 – 20 diazepam: 15 – 30 lorazepam: 60 – 120 ketamine: 5 – 10 etomidate: 3-8 dexmedetomidine: N/A |
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Vd55 (min)
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Propofol: 2-10
thiopental: 2.5 Methohexital: 2.2 midazolam: 1.1 – 1.7 diazepam: 0.7 – 1.7 lorazepam: 0.8 – 1.3 ketamine: 3.1 Etomidate: 2.5 – 4.5 dexmedetomidine: 2-3 |
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T 1/2 a (min)
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Propofol: 2-4
thiopental: 2-4 methohexital: 5-6 midazolam:7-15 diazepam: 10-15 lorazepam: 3-10 ketamine: 11-16 etomidate: 2-4 dexmedetomidine: 6 |
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Protein binding (%)
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Propofol: 97
thiopental: 83 methohexital: 73 midazolam: 94 diazepam: 98 lorazepam: 98 ketamine: 12 etomidate: 77 dexmedetomidine: 94 |
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Clearance (ml/kg/min)
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Propofol: 20 – 30
Thiopental: 3.4 methohexital: 11 midazolam: 6.4 – 11 diazepam: 0.2 – 0.5 lorazepam: 0.8 – 1.8 ketamine: 12 – 17 etomidate: 18 – 25 dexmedetomidine: 10 – 30 |
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T1/2 B (hr)
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Propofol: 4-23
Thiopental: 11 methohexital: 4 midazolam: 1.7 – 2.6 diazepam: 20 – 50 lorazepam: 11 – 22 ketamine: 2-4 etomidate: 2.9 – 5.3 dexmedetomidine: 2-3 |
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Propofol induction dose (mg/kg IV)
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1-2.5
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Thiopental induction dose
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3-5
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Methohexital induction dose
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1.0-1.5
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Midazolam induction dose
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0.1 – 0.3
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Diazepam induction dose
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0.3 – 0.6
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Lorazepam induction dose
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0.03 – 0.1
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Ketamine induction dose
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1.0 – 2.0
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Etomidate induction dose
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0.2 – 0.3
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Dexmedetomidine induction dose
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N/A
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Propofol duration of action (min)
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3-8
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Thiopental duration of action
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5-10
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Methohexital duration of action
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4-7
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Midazolam duration of action
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15 – 20
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Diazepam duration of action
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15 – 30
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Lorazepam duration of action
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60 – 120
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Ketamine duration of action
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5-10
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Etomidate duration of action
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3-8
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Dexmedetomidine duration of action
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N/A
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Propofol VD55 (min)
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2-10
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Thiopental VD55 (min)
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2.5
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Methohexital VD55 (min)
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2.2
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Midazolam VD55 (min)
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1.1 – 1.7
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Diazepam VD55 (min)
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0.7 – 1.7
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Lorazepam VD55 (min)
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0.8 – 1.3
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Ketamine VD55 (min)
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3.1
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Etomidate VD55 (min)
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2.5 – 4.5
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Dexmedetomidine VD55 (min)
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2-3
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Propofol T 1/2 a (min)
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2-4
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Thiopental T 1/2 a
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2-4
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Methohexital T 1/2 a
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5-6
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Midazolam T 1/2 a
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7-15
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Diazepam T 1/2 a
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10-15
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Lorazepam T 1/2 a
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3-10
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Ketamine T 1/2 a
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11 – 16
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Etomidate T 1/2 a
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2-4
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Dexmedetomidine T 1/2 a
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6
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Propofol protein binding (%)
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97
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Thiopental protein binding
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83
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Methohexital protein binding
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73
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Midazolam protein binding
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94
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Diazepam protein binding
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98
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Lorazepam protein binding
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98
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Ketamine protein binding
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12%
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Etomidate protein binding
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77%
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Dexmedetomidine protein binding
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94%
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Propofol clearance (mg/kg/min)
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20 – 30
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Thiopental clearance
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3.4
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Methohexital clearance
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11
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Midazolam clearance
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6.4 – 11
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Diazepam clearance
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0.2 – 0.5
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Lorazepam clearance
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0.8 – 1.8
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Ketamine clearance
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12 – 17
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Etomidate clearance
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18 – 25
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Dexmedetomidine clearance
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10 – 30
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Propofol T1/2 B (hr)
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4-23
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Thiopental T1/2 B (hr)
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11
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Methohexital T1/2 B (hr)
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4
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Midazolam T1/2 B (hr)
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1.7 – 2.6
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Diazepam T1/2 B (hr)
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20 – 50
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Lorazepam T1/2 B (hr)
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11 – 22
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Ketamine T1/2 B (hr)
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2-4
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Etomidate T1/2 B (hr)
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2.9 – 5.3
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Dexmedetomidine T1/2 B (hr)
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2-3
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Dose for induction of anesthesia (mg/kg IV)
(propofol, thiopental, midazolam, ketamine, etomidate, dexmedetomidine) |
Propofol: 1.5 – 2.5
thiopental: 3-5 midazolam: 0.1 – 0.3 ketamine: 1-2 etomidate: 0.2 – 0.3 dexmedetomidine: |
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Effect on systemic blood pressure
(propofol, thiopental, midazolam, ketamine, etomidate, dexmedetomidine) |
Propofol: decreased
thiopental: decrease midazolam: unchanged to decrease ketamine: increase etomidate: decreased dexmedetomidine: decreased |
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Effect on heart rate
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Propofol: unchanged to decrease
thiopental: increased midazolam: unchanged ketamine: increased etomidate: unchanged to increase dexmedetomidine: decrease |
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Effect on systemic vascular resistance
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Propofol: decrease
thiopental: decreased midazolam: unchanged to decrease ketamine: increase Etomidate: unchanged to decrease dexmedetomidine: decrease |
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Effect on ventilation
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Propofol: decrease
thiopental: decrease midazolam: unchanged ketamine: unchanged etomidate: unchanged decrease dexmedetomidine: unchanged |
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Effect on respiratory rate
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Propofol: decrease
thiopental: decrease midazolam: unchanged ketamine: unchanged etomidate: unchanged to decreased dexmedetomidine: unchanged |
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Effect on response to carbon dioxide
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Propofol: decreased
thiopental: decrease midazolam: unchanged ketamine: unchanged etomidate: decrease dexmedetomidine: unchanged |
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Effect on cerebral blood flow
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Propofol: decreased
thiopental: decreased midazolam: unchanged ketamine: increased to unchanged etomidate: decreased dexmedetomidine: unchanged |
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Effect on cerebral metabolic requirements for oxygen
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Propofol: decreased
thiopental: decreased midazolam: unchanged ketamine: increased to unchanged etomidate: decreased dexmedetomidine: unchanged to decreased |
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Effect on intracranial pressure
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Propofol: decreased
thiopental: decreased midazolam: unchanged ketamine: unchanged to increased etomidate: decreased dexmedetomidine: unchanged |
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Anticonvulsant effect
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Propofol: unclear
thiopental: yes midazolam: yes ketamine: unclear etomidate: no |
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Anxiolytic effect
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Propofol: no
thiopental: no midazolam: yes ketamine: no etomidate: no dexmedetomidine: yes? |
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Analgesia?
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Propofol: no
thiopental: no midazolam: no ketamine: yes etomidate: no dexmedetomidine: no? |
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Emergence delirium?
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Propofol: no?
Thiopental: no midazolam: no ketamine: yes Etomidate: no dexmedetomidine: no |
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Nausea and vomiting
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Propofol: decreased
thiopental: unchanged midazolam: unchanged to decreased ketamine: unchanged etomidate: increased dexmedetomidine: unchanged |
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Adrenocortical suppression
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Propofol: no
thiopental: no midazolam: yes? Ketamine: no etomidate: yes dexmedetomidine: no |
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Pain on injection
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Propofol: yes
thiopental: no midazolam: no ketamine: no etomidate: no dexmedetomidine: no |
