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10 Cards in this Set
- Front
- Back
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How are most IV agents excreted?
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Kidneys
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Describe the physical characteristics of barbiturates
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Highly lipid soluble, highly protein bound, highly non-ionized
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What is the induction speed of barbiturates?
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30 seconds
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What is the duration of action of barbiturates?
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8-12 minutes (d/t redistribution)
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What is the MOA of barbiturates?
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Potentiating of GABA -> depression of the RAS
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What is the RAS?
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A polysnaptic pathway in the cerebral cortex which determines the overall level of CNS activity and sleep/wake
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What are the CV effects of barbiturates?
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Minimal SBP drop d/t peripheral vasodilation, decreased venous return and thus decreased CO. Increase in HR d/t baroreceptor response to vasodilation. Negative ionotropy.
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What are the respiratory effects of barbiturates?
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Transiet apnea from medullary depression, decreased VT and RR upon emergence (may require assisted ventilation)
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Do barbiturates depress airway and laryngeal reflexes?
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No
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Can barbiturates alone be used to intubate someone?
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No, because airway/laryngeal reflexes are intact, laryngospasm may result
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