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14 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What is myocardial ischaemia?
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A decrease in blood flow to myocardium due to blockage of coronary artery
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What is angina
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Chest pain result of ischaemia
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What causes ischaemia?
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Atherosclerosis and vasospasm
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How is ischaemia/angina treated?
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Increase oxygen supply or decrease demand
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Decreasing demand is more effective especially with atheroclerosis as person is unable to ob
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What is an important regulator of coronary blood flow?
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Adenosine (from ATP) --> vasodilator
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Oxygen demand is reduced using..
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nitrtates, B blockers, calcium blockers
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Describe how nitrates help ischemia
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Venodilators thus reduce venous blood return to heart thus decrease demand of myocardium
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Nitrates are converted to what?
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NO - activates cGMP synthesis decrease Ca entry--> muscle relaxes
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Describe how B blockers help angina
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Preventitive - decreases HR, which leads to increase blood flow to left ventricular tissue
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Diastole
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relax
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Systole?
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contract
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How do calcium channel blockers help angina?
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Preventitive - causes vasodilation
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What do If channel blockers do?
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Reduce HR thus reduce oxygen demand and increase oxygen supple
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When are coronary arteries open?
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During diastole
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