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15 Cards in this Set
- Front
- Back
What is the normal daily requirement of iron? |
20-25 mg |
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What type of anemia is resultant of iron deficiency? |
Microcytic Anemia |
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What factors contribute to increasing the absorption of iron from the GI Tract? |
Acids (HCl and Vit. C), Inorganic Iron, Ferrous Iron, Agents that solubilize iron: Sugar, Amino Acids, Iron Deficiency, Increased Demand: Pregnancy, Infancy, Adolescence, Haemolysis, bleeding, Primary Haemochromatosis |
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What factors can lead to a decrease in he amount of iron absorbed from the GIT? |
Alkalis, Antacids, Organic Iron, Ferric Iron, Agents that precipitate iron, phytates (ionic form of phytic acids) which is found in tea, excess iron, decreased utilisation (inflammation, infection), gastrectomy, GIT abnormalities, achlorhydria. |
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What is achlorhydria? |
Absence of HCl in the stomach. |
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What is Primary Haemochromatosis |
It is an autosomal recessive disease that causes abnormal accumulation of iron in parenchymal organs in the form of hemosiderin. It causes organ toxicity and damage and is the most common cause of severe iron overload. |
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What percent of the body's iron is used in hemoglobin? |
60-70% |
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What percent of the body's iron is stored as ferritin or hemosiderin? |
16-29% |
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What percent of the body's iron is used functionally (i.e. as catalase, myoglobin, cytochrome, etc.) |
10-12% |
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What are some common causes of iron deficiency? |
1. Chronic blood loss as caused by uterine or GIT bleeding by peptic ulcer, carcinoma, hookworm, piles, aspirin or other non steroidal anti-inflammatory drugs and also rarely by Haematuria. 2. Increased demand has caused by prematurity, growth, childbearing. 3. Malabsorption as caused by gastrectomy, Coeliac diseases. 4. Poor Diet. |
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What is a Coeliac disease? |
A condition where the small intestines is inflamed and unable to absorb nutrients. |
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What is Apparent Anemia? |
This is form of anemia that results from acute blood loss. It is due the body producing large quantities of plasma to replace loss blood, which results in a reduction in the conc. of RBCs. |
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What is caeruloplasmin? |
It is a copper-containing enzyme that catalyzes the oxidation of iron into its ferric form for binding to plasma transferrin. |
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Which enzyme, found in enterocytes, converts ferric iron into ferrous iron so that they can be absorbed from the GIT? |
Ferrireductase |
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Which enzyme found inside enterocytes converts ferrous iron into ferric iron so that it can be bound to transferrin? |
Hephaestin (Ferrioxidase) |