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26 Cards in this Set
- Front
- Back
Reduced form of Iron |
Fe2+ |
|
Oxidized form of iron |
Fe3+ |
|
Heme iron is found in Plant or Animal foods? |
Animal |
|
Non-heme iron is found in plant or animal foods/ |
Plant |
|
Heme synthesis is initiated in the |
Mitochondrial matrix |
|
Hemoglobin contains four of |
Polypeptide chains, O2 molecules, Fe molecules, and heme groups |
|
Heme iron is transported by |
Heme Carrier Protein 1 (hcp1) |
|
Free Iron is reduced from Fe3+ to Fe2+ by |
Hcl and reductases |
|
Free iron is transported by |
DMT1 |
|
Absorption enhancers |
Sugars, acids, acidic pH, Meat, fish |
|
Absorption inhibitors |
Alkaline pH, polyphenols, oxalic acid, Phytic acid, |
|
True or False: A lot of Fe is found free in cytosol |
false |
|
Heme is hydrolyzed by ____ to release Fe2+ |
Heme oxygenase |
|
Heme is exported into circulation by |
Ferroportin |
|
Fe can be stored as |
Ferritin |
|
Increased Fe in the cell reduced the expression of what transporter |
DMT1 |
|
Transports iron in the blood to organs |
Transferrin |
|
Transferrin only binds to |
Fe3+ |
|
Iron in circulation is found mostly as |
Fe3+ oxidized form |
|
Every time Iron is mobilized it is found as |
Fe2+ |
|
____ is secreted by the liver when the levels of Iron are high |
Hepcidin |
|
Fe bound to transferrin (Tf) is taken up by the ___ by receptor mediated endo |
Transferrin receptor (TfR)
|
|
TfR is present at the _____ of all cells |
Plasma membrane |
|
Insert O2 into a substrate requiring single Fe for A.A. metab |
Monoxygenase |
|
Insert two O2 into a substrate for Nitric oxide synthase |
Dioxygenase |
|
Nitric oxide is synthesized from what A.A. |
arginine |