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42 Cards in this Set

  • Front
  • Back
Pancreatic hormones of the pancreas are produced by what two groups of cells?
Alpha Cells
Beta Cells
Alpha Cells produce this hormone
Glucagon
Beta Cells produce this hormone
Insulin
What counterregulatory hormones are produced in the body and what is their action?
Counterregulatory hormones are hormones that work in opposition to the action of insulin. These are Growth hormone, catecholamines, and cortisol.
What is gluconeogenisis
The conversion of amino acids to glucose.
Insulin is:
the principle regulator of the metabolism and storage of ingested CHO's, fats and proteins. Insulin facilitates glucose transport across cell membranes in most tissues.
Number one minority group affected by Diabetes Mellitus
Native American Population
2)HIspanic
3)African American
4) Asian
Characteristics of Type I Diabetis Mellitus (the typical presentation)
Onset 11-13 years of age (but can occur at any age), lean body type(but can occur in over weight), 5-10% incidence, long preclinical period but rapid onset, positive antibody in islet cells, severe insulin deficiency
Auto antibodies that destroy the pancreatic beta cells
Tpe I
Type II characteristics
> 90% of the population, onset usually > 40yrs old, associated with obesity, insidious onset, insulin resistance but still produces insulin
what type of diabetes is characteristic here:
polydipsia
polyuria
polyphagia
Type I
Weight loss and fatigue are characteristics of which diabetes?
Type I
Insulin deficiency is a characteristic of what diabetes?
Type I
Pancreas continues to produce some endogenous insulin, diabetes____?
Type II
Type II may have the three p's plus other non-specific s/s. Please name the three p's and four other s/s.
polyphagia.
Recurrent infections, genital pruritus, visual changes, paresthesis
As the blood stream becomes more hypertonic from increased b/g what pathophysiological changes take place (circulatory, uro)?
Water is pulled from the cells causing an increase in blood volume, causing diuresis. Pt. becomes polyuric then they are thirsty(polyphagic).
What metabolic changes of the cells take place in the presence of diabetes?
Glucose does not enter the cells so hunger persists in an effort to get more 'food' to the cells, pt. has fatigue because sugar does not enter the cell.
What methods are used to test for and diagnose Diabetes Mellitus>
1) FPG- fasting plasma glucose > = 126mg/dl (If overt s/s 3p's are present, second OGTT may not be needed for diagnosis)
2) Random or casual , plasma glucose measurement =>200mg/dl
3)Two hour OGTT level => 200 mg/dl using a glucose load of 75g.
The normal FPG range, prediabetic range:
normal: 70-100
impaired: 101-125
Normal OGTT or random range:
Normal should be < 140
Impaired is 140-199
What does the Glycolylated Hemoglobin (HgA1C) test and what is the normal range versus the goal for a diabetic patient?
The glucose attaches to the RBC and stays attached throught the life cycle of the cell, Hg A1C tests the average blood glucose for 90-120 days. Normal is 4-6%, the goal of a diabetic patient is 6.5-7%.
True or false HgA1C is used as a diagnostic tool for testing Diabetes Mellitus?
False, it is only used once the diagnosis has been made to track the glucose control the patient is achieving with their blood sugar control.
Urine tests used in Diabetes?
There is a glucose uria test but renal thresholds for glucose differes among individuals, so this is not a great method of testing.
Also a ketoneuria test is used in Type I.
When is the ketoneuria test performed?
During acute illness
BG > 250
Pregnancy
s/s ketoacidosis
2 main s/s on ketoacidosis
n/v & abd pain
When the diabetic patient has n/v and abd pain what steps should be taken to insure their safety?
They should go to the hospital immediately, this indicated the presence on ketones, pt. is already breaking down their fat.
describe DKA pathiophysiology
when the circulating supply of insulin is insufficient and glucose cannot enter the cell for the body's energy, the body breaks down fat stores as a secondary source of fuel. Keytones are acidic by-products of fat metabolism that can can alter the pH of the blood. (see pg 1279)
The compensatory response to metabolic acidosis (DKA) is to ___ CO2 excretion from the ___. The patient often develops ___ ___. In addition the kidneys attempt to excrete additional ___.
increase, lungs, Kussmaul respiration (deep, rapid breathing), acid
What test is used to check health status of kidneys in diabetic pt. What does it check for?
24 hour creatinine clerance test to check for protiens in the urine. Protien should not be in urine.
who should use the SMBG testing?
All pts. with diabetes especially those on exogenous insulin.
When should pts. use SMBG?
When there:
1) Any changes in therapy
2)Ilness/pregnancy
3) s/s of hypo or hyper glycemia
4) 4 'befores'--before breakfast, lunch, dinner, bedtime
True/false:
Alcohol wipes should be used at home for finger sticks.
False: use only soap and water to cleanse finger or other area when at home SMBG testing.
If tested + for Islet Cell Antibody there is a __ chance in developing Type ___.
10%, Type I
Time frame for diabetes testing and screening in the life span.
OGTT or fasting at 45 yrs and if normal repeat q3yrs. If child is obese and family hx do earlier. Do earlier and more often if high-risk.
who is high risk for diabetes?
family history
obese
women with macrosomic babies >9 lbs or GDM
hypertensive and/or hyperlipidemic
American Indian, Hispanic, African American
Impaired FG or glucose tolerance
primary goal of diabetes care
to keep b/s levels in normal limits, to try to make as normal as possible
what is the best approach formaintaining the goals of diabetes care?
proper nutrition, exercise, medication, education, monitoring
Normal values for:
FBS
HS glucose
HgbA1C
FBS: 80-120
HS glucose:100-140
HgbA1C- 6.5-7% or lower
3 cornerstones for diabetic treatment
meds, diet, exercise
what should the goals of the diabetic patient be for achieving optimum serum lipid levels?
Reduce current weight by 10%, moderate caloric restriction works best, focus on polyunsaturated fats (avacado), eliminate saturated fat.
draw the visual tool on the dinner plate helpful in teaching patients a basic guide in what to eat
1/2 plate non starchy veggies and fruits, 1/4 proteins, 1/2 CHO (complex)
proteins should comprise what % of the diet?
15-20%, or 10% if + for diabetic nephropathy (when kidney tests + for protein)