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29 Cards in this Set
- Front
- Back
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What are NRTIs |
analogs of deoxynucleotides used in DNA synthesis to be added to chain |
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Method of action of NRTIs |
Inhibit viral transcriptase |
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Structure of NRTIs |
Lacking 3-hydroxyl on deoxyribose ring inhibits nucleotide formation of 5' to 3' chain of DNA |
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Abacavir generic |
(ABC) Ziagen |
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Abacavir dosage form |
PO- Tablet / Solution 300-600mg Q12-24H |
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Ematricabine (generic) |
FTC Emtriva |
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Ematricabine dosage forms |
(PO) Capsule 200mg QD Solution 240 mg QD |
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Lamuvidine (Generic) |
3TC Epivir |
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Lamuvidine dosage |
(PO) tablet/solution 150- 300mg Q12- 24H |
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Tenofovir Disoproxil Fumerate (generic) |
TDF Viread |
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Tenofovir Dosage |
(PO) Tablet 300 mg QD Powder 300 mg / 7.5 scoops w/ 2- 4 oz of food 40 mg/scoop |
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Zidouvadine (Generic) |
AZT Retrovir |
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Zidouvadine dosage forms |
(PO) cap, tab, solution- 200mg-300mg Q8-12H (IV) 1mg/kg over a hour Q4H |
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Drug interactions of NRTIs |
Nephrotoxic, Hepatotoxic, alcohol, Bone marrow depression, doxorubicin |
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Labs for NRTI therapy |
CBC w/ differential, CD4+ Tcell count, HIV RNA,LFTs |
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Lab For Abacavir |
Pre-treatment HLA-B5101 a positive read = hypersensitivity |
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Which drug requires Hep B V testing |
Emitrictabine, Lamuvidine, Tenofovir |
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Testing for Lamuvidine |
Serum Phosphorous, Serum Creatine, Bone Density |
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BBW for all NRTIs |
Lactic Acidosis, Hepatotoxicity |
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Side Effects of Zidouvidine |
Bone Marrow Suppression BBW- Anemia, neutropenia, myopathy |
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Side effects of Zidouvadine, Stavudine, Didanosine |
Lactic Acidosis, Hepatomegally, Steatosis. |
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Tenofovir side effects |
Acute hepatitis exacerbation in Hep B, acute Renal failure, fanconi syndrome *preferred for 1xday |
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Emtrictabine Side effects |
(BBW)Acute hepatitis exacerbation in Hep B, skin hyper pigmentation |
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Abacavir side effects |
fatal hypersensitivity , increases risk of MI |
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Which drug is preferred in pregnancy |
Zidouvidine |
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Truvada (Brand) |
Tenofovir + Emtrictabine * Drug of choice for pre-exposure prophylaxis |
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Contraindications of NRTIs |
Hepatotoxicities, Hypersensitivity, pre exposure, unknown status, |
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Which drugs require a prior Hep B |
Emtrictabine, Lamuvidine, Tenofovir |
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Testing for Lamuvidine |
Serum phosphorous, Serum Creatine , Bone density |
