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14 Cards in this Set
- Front
- Back
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What are some examples of triple drug therapy for H.pylori erradication?
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Metronidazole+clarithromycin+omeprazole
Metronidazole+amoxycillin+omeprazole Nexium Klacid HP |
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What are the drug therapies for peptic ulcer disease?
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H2 antagonists
Proton pump inhibitors Sucralfate Prostaglandin analogues |
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What is the mode of action of antacids?
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They neutralise gastric acid
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What are the side effects of antacids?
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GIT effects
Constipation Hypercalcaemia |
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What are some examples of H2 antagonists?
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Cimetidine
Ranitidine Famotidine Nizatidine |
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What is the mode of actionof H2 antagonists?
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Inhibit the secretion of gastric acid by blocking the H2 receptors on the parietal cells
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What are the side effects of H2 antagonists?
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Diarrhoea
Nausea Constipation Headache Dizziness Skin rash |
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What are some examples of proton pump inhibitors?
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Omeprazole
Lansoprazole Pantoprazole |
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What is the mode of action of PPI's?
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Inhibit the enzyme H+/K+ATPase, located on luminal surface of gastric parietal cells
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What are the side effects of PPI's?
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Diarrhoea
Nausea Headache Abdominal pain |
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What is the drug therapy for GORD?
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Antacids
H2 blockers PPI's Sucralfate Metaclopramide Domperidone |
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What are the drug/nutrient interactions with antacids?
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Vit C - inreases absorption, separate dose
Folate and Fe - reduced absorption, separate dose |
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What are the drug/nutrient interactions with PPI's & H2 antagonists?
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Folate - reduced absorption
Iron - reduce effects, supplement B12 - reduced absorption |
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What are the herb/drug interactions with H.pylori triple drug therapy?
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Garlic - beneficial additive effects
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