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15 Cards in this Set
- Front
- Back
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Name for the monobactams
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Aztreonam (Azactam)
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What is the antibacterial spectrum for Monobactam
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gram negative without gram pos or anaerobic action
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Is Monobactam resistant to B lactamases?
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yes
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What is the use for Monobactam?
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alternative to aminoglycosides in patients with diminished renal function
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What is the probability that Monobactams will have a allergic reaction with other beta lactam agents?
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low
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What are the routes for Aztreonam (Azactam)?
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IV and IM routes
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What are the synthetic B lactams with similar MOA to the real B lactams?
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Carbapenems
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What is the spectrum of Carbapenems?
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broadest available--cover everything including moderate MRSA
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Carbapenems are first line for what?
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Enterobacter, Pseudomonas, and Serratia
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What are the three carbapenems?
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Imipenem/cilastatin (Primaxin) and Meropenem and Ertapenem
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What is the purpose of Cilastatin?
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it is a dehydropeptodase inhibitor that protects drug from cleavage and prevents formation of a toxic metabolite
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What are Carbapenems used for?
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They cover everything, but are saved for last ditch effort when PCN, Ceftazidime, and 3rd or 4th generation Cephalosporins fail
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Side effects of Carbapenems
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N/V, rashes, seizures
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What percentage of cross reactivity do Carbapenems have with PCN?
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50%
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Clinical use for carbapenems
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febrile neutropenia, severe resistant infections
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