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59 Cards in this Set

  • Front
  • Back
Essentials of diagnosis for CKD
progressive azotemia over months/years; S/S uremia when nearing ESD; HTN; isothenuria and broad, waxy casts in urinary sediment, bilateral small kidneys on US
Definition of CKD
evidence of renal damage based on abnormal UA or structural abnormalities OR GFR < 60 ml/min for 3+ mths
Most common RF for CKD
DM, HTN, CAD, Family History of CKD, age over 60
What does reduction in renal mass lead to in CKD?
hypertrophy of remaining nephrons with hyperfiltration (GFR is transient supranormal); the remaining nephrons are burdened and sclerose and fibrose worsening the failure
Manifestations of far advanced renal failure
fatigue, malaise, weakness, pruritis
Gig complaints in renal failure
anorexia, N/V, metallic taste, hiccups
Describe symptom progression In CKD
slow developing and nonspecific symptoms; patients are asymptomatic often until GFR less than 15
neurologic problems caused by CKD
irritability, difficulty concentrating, insomnia, forgetfulness
Reproductive/Genital symptoms of CKD
menstrual irregularities, infertility, loss of libido
What are Mee's lines?
nail changes found in CKD
What is uremic fetor?
fishy breath in CKD
What skin changes are there in CKD?
yellow with easy bruising, pruritis
How is diagnosis of CKD made?
documenting elevations of BUN and serum creatinine concentrations
Once the GFR drops below 60, what should be done?
refer to nephrologist
What is suggestive of CKD even in the absence of reduced GFR?
persistent protienuria
What is seen on UA of CKD?
broad, waxy casts (the tubules have lost their concentrating ability)
Electrolyte changes that may be seen in CKD
hyperphosphatemia, hypocalcemia, hyperkalemia
Finding of small echogenic kidneys on ultrasound supports what diagnosis?
CKD or irreversible disease
What X ray finding may help to diagnose CKD?
renal osteodystrophy (check phalanges of hands and clavicles)
What uremic complication causes over half of deaths in CKD?
Cardiovascular disease
MC complication of CKD
HTN
What causes most of the acid base disorders in chronic kidney disease?
tend to retain H ions
What is considered a small kidney?
less than 9 cm
Normal size of kidney
10-12 cm in adult
How do you treat HTN in patient with CKD?
weight loss, tobacco sensation, reduce salt intake to 2 g/day or less, ACE- I or ARB, and SMOKING CESSATION
BP goal in CKD
less than 130/80; if protienuria greater than 1-2 g/day, the goal is 125/75
What is the BP goal for patient with protienuria in CKD?
125/75
What is the cause of pericarditis in CKD?
retention of metabolic waste
Symptoms of endocarditis
chest pain and fever; maybe pulsus paradoxus or friction rub on exam
Pericarditis is an absolute indication for initiation of _____________.
dialysis
How should you treat CHF in patient with CKD?
loop diuretic, ACE-I, and regulation of salt and water
Patients with ESRD have a ________ cardiac output along with HTN and atherosclerosis that increase LVK and dilation.
high
The potassium balance usually remains intact until the GFR is below what?
10-20 ml/min
What is included for tx of hyperkalemia?
cardiac monitoring, IV calcium chloride or glutanate, insulin with glucose, bicarb, and sodium polystrene sulfonate
What is used to treat chronic hyperkalemia?
dietary potassium restriction and sodium polystrene PRN
pH that is absolute for initiation of dialysis
below 7.2
What is metabolic acidosis in CKD usually a result of?
loss of renal mass so kidneys cannot excrete the acid produced daily by the body
Tx for metabolic acidosis?
maintain serum bicard above 21
What is anemia in CKD caused by?
decreased erythropoeisis and RBC survival
Main cause of coagulopthy in CKD
platelt dysfunction
Progression of uremic encephalopathy in CKD
GFR drops below 10-15; difficulty concentrating --> lethargy --> confusion --> coma
What is renal dystrophy a disorder of?
calcium, phosphorous, and bone
MC disorder of mineral metabolism
osteitis fibrose cystica- bony changes secondary to hyperparathyroidism
Where are renal bone lesions most commonly found?
phalanges of fingers and lateral ends of clavicles
Why are circulating insulin levels increased in CKD?
decreased renal insulin clearance
What is the cause of glucose intolerance in CKD?
peripheral insulin resistance
Tx for CKD in general
stop smoking, ACE/ARB to slow protienuria and CVD, Diabets control, lower cholesterol w/ statin, avoid fluid overload w/ Lasix, CKD clinic involvement
Why should every CKD patient see dietician?
malnutrition is commonl; also need protein, salt/water, potassium, phosphorous, and magnesium restriction
In general protein intake should not exceed what amount daily?
1 g/kg/day
In general what is the initial recommendation for salt restriction?
2 g/d or less
What GFR and serum creatinine should you start dialysis at?
under 10 ml/min and 6 mg/dl
What GFR do diabetics start dialysis at?
under 15 ml/min
How is vascular access accompished in hemodialysis?
preferred AV fistula, but also prosthetic graft
MC cause of infection in dialysis patients
Staph Aureus
MC type of dialysis
hemodialysis
MC PD complication
peritonitis (Staph Aureus)
MC type of Peritoneal Dialysis
continuous ambulatory peritoneal dialysis
Infection, thrombosis, and aneurysm formation are comlications found more in (AV fistula or graft) used in dialysis? Choose
graft
MC cause of death in CKD
cardiac dysfunction