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59 Cards in this Set
- Front
- Back
Essentials of diagnosis for CKD
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progressive azotemia over months/years; S/S uremia when nearing ESD; HTN; isothenuria and broad, waxy casts in urinary sediment, bilateral small kidneys on US
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Definition of CKD
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evidence of renal damage based on abnormal UA or structural abnormalities OR GFR < 60 ml/min for 3+ mths
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Most common RF for CKD
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DM, HTN, CAD, Family History of CKD, age over 60
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What does reduction in renal mass lead to in CKD?
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hypertrophy of remaining nephrons with hyperfiltration (GFR is transient supranormal); the remaining nephrons are burdened and sclerose and fibrose worsening the failure
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Manifestations of far advanced renal failure
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fatigue, malaise, weakness, pruritis
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Gig complaints in renal failure
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anorexia, N/V, metallic taste, hiccups
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Describe symptom progression In CKD
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slow developing and nonspecific symptoms; patients are asymptomatic often until GFR less than 15
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neurologic problems caused by CKD
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irritability, difficulty concentrating, insomnia, forgetfulness
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Reproductive/Genital symptoms of CKD
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menstrual irregularities, infertility, loss of libido
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What are Mee's lines?
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nail changes found in CKD
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What is uremic fetor?
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fishy breath in CKD
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What skin changes are there in CKD?
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yellow with easy bruising, pruritis
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How is diagnosis of CKD made?
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documenting elevations of BUN and serum creatinine concentrations
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Once the GFR drops below 60, what should be done?
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refer to nephrologist
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What is suggestive of CKD even in the absence of reduced GFR?
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persistent protienuria
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What is seen on UA of CKD?
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broad, waxy casts (the tubules have lost their concentrating ability)
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Electrolyte changes that may be seen in CKD
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hyperphosphatemia, hypocalcemia, hyperkalemia
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Finding of small echogenic kidneys on ultrasound supports what diagnosis?
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CKD or irreversible disease
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What X ray finding may help to diagnose CKD?
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renal osteodystrophy (check phalanges of hands and clavicles)
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What uremic complication causes over half of deaths in CKD?
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Cardiovascular disease
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MC complication of CKD
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HTN
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What causes most of the acid base disorders in chronic kidney disease?
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tend to retain H ions
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What is considered a small kidney?
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less than 9 cm
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Normal size of kidney
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10-12 cm in adult
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How do you treat HTN in patient with CKD?
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weight loss, tobacco sensation, reduce salt intake to 2 g/day or less, ACE- I or ARB, and SMOKING CESSATION
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BP goal in CKD
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less than 130/80; if protienuria greater than 1-2 g/day, the goal is 125/75
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What is the BP goal for patient with protienuria in CKD?
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125/75
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What is the cause of pericarditis in CKD?
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retention of metabolic waste
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Symptoms of endocarditis
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chest pain and fever; maybe pulsus paradoxus or friction rub on exam
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Pericarditis is an absolute indication for initiation of _____________.
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dialysis
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How should you treat CHF in patient with CKD?
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loop diuretic, ACE-I, and regulation of salt and water
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Patients with ESRD have a ________ cardiac output along with HTN and atherosclerosis that increase LVK and dilation.
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high
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The potassium balance usually remains intact until the GFR is below what?
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10-20 ml/min
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What is included for tx of hyperkalemia?
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cardiac monitoring, IV calcium chloride or glutanate, insulin with glucose, bicarb, and sodium polystrene sulfonate
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What is used to treat chronic hyperkalemia?
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dietary potassium restriction and sodium polystrene PRN
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pH that is absolute for initiation of dialysis
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below 7.2
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What is metabolic acidosis in CKD usually a result of?
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loss of renal mass so kidneys cannot excrete the acid produced daily by the body
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Tx for metabolic acidosis?
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maintain serum bicard above 21
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What is anemia in CKD caused by?
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decreased erythropoeisis and RBC survival
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Main cause of coagulopthy in CKD
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platelt dysfunction
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Progression of uremic encephalopathy in CKD
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GFR drops below 10-15; difficulty concentrating --> lethargy --> confusion --> coma
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What is renal dystrophy a disorder of?
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calcium, phosphorous, and bone
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MC disorder of mineral metabolism
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osteitis fibrose cystica- bony changes secondary to hyperparathyroidism
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Where are renal bone lesions most commonly found?
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phalanges of fingers and lateral ends of clavicles
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Why are circulating insulin levels increased in CKD?
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decreased renal insulin clearance
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What is the cause of glucose intolerance in CKD?
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peripheral insulin resistance
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Tx for CKD in general
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stop smoking, ACE/ARB to slow protienuria and CVD, Diabets control, lower cholesterol w/ statin, avoid fluid overload w/ Lasix, CKD clinic involvement
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Why should every CKD patient see dietician?
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malnutrition is commonl; also need protein, salt/water, potassium, phosphorous, and magnesium restriction
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In general protein intake should not exceed what amount daily?
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1 g/kg/day
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In general what is the initial recommendation for salt restriction?
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2 g/d or less
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What GFR and serum creatinine should you start dialysis at?
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under 10 ml/min and 6 mg/dl
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What GFR do diabetics start dialysis at?
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under 15 ml/min
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How is vascular access accompished in hemodialysis?
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preferred AV fistula, but also prosthetic graft
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MC cause of infection in dialysis patients
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Staph Aureus
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MC type of dialysis
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hemodialysis
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MC PD complication
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peritonitis (Staph Aureus)
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MC type of Peritoneal Dialysis
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continuous ambulatory peritoneal dialysis
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Infection, thrombosis, and aneurysm formation are comlications found more in (AV fistula or graft) used in dialysis? Choose
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graft
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MC cause of death in CKD
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cardiac dysfunction
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