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25 Cards in this Set
- Front
- Back
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WHAT PERCENT OF THYROID HORMONE IS BOUND TO CARRIER PROTEINS?
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99%- BOUND TO THYROID/THYROXIN BINDING GLOBULIN; THYROXIN BINDING PREALBUMIN, AND ALBUMIN
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SINGLE MOST USEFUL THYROID FUNCTION TEST
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SERUM THYROID STIMULATING HORMONE
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IF THERE IS LOW TSH, WHAT CONDITIONS COULD BE PRESENT?
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PRIMARY HYPERTHYROIDISM; EXOGENOUS THYROID HORMONE ADMINISTRATION
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WHAT ARE THE THREE THYROID HORMONES?
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TSH (COMES FROM THE PITUITARY TO THE THYROID); T4 (MAJOR SECRETORY PRODUCT OF THYROID); T3- PRODUCED IN PERIPHERAL TISSUES FROM T4---IT IS THE PHYSIOLOGICALLY ACTIVE HORMONE
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WHAT EFFECT DOES T3 HAVE ON PHYSIOLOGIC FUNCTIONS?
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INCREASES O2 CONSUMPTION AND METABOLIC RATE; INCREASES HEAT PRODUCTION; INCREASES PLASMA LEVELS OF FREE FATTY ACIDS; INCREASES PROTEIN SYNTHESIS AND DEGRADATION; ENHANCES GLUCONEOGENESIS AND INCREASES GLUCOSE ABSOPRTION; UP REGULATES CATECHOLAMINE RECEPTORS
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IF THERE IS ELEVATED TSH, WHAT CONDITIONS COULD BE PRESENT?
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PRIMARY HYPOTHYROIDISM, SECONDARY HYPERTHYROIDISM (EXCESS TSH FROM PITUITARY)
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WHAT IS THE USE FOR SERUM FREE T4?
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USED AS SCREENING TEST ALONG WITH TSH; DIRECT MEASURE OF UNBOUND T4; USED TO MONITOR T4 SECRETION IN PATIENTS WITH HYPERTHYROIDISM
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WHAT DO WE USE TESTS OF THYROID AUTOIMMUNITY FOR?
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THEY ARE USE DONLY TO TEST FOR GRAVE'S OR HASHIMOTO'S THYROIDITISQ
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WHAT IS THE ROLE OF THYROID STIMULATING IMMUNOGLOBULIN?
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ACTIVATES TSH RECEPTORS- RESULTS IN HYPERTHYROIDISM
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WHAT ARE THE LAB FINDINGS IN PRIMARY HYPOTHYROIDISM?
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INCREASED TSH, DECREASED T4--- THYROID DOESN'T RESPOND TO THE TSH BY MAKING T4; THE PITUITARY CONTINUES TO MAKE TSH TRYING B/C THERE IS A LOW T4
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WHAT ARE THE LAB FINDINGS IN PRIMARY HYPERTHYROIDISM?
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TSH IS LOW AND THE T4/T3 ARE HIGH
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WHAT IS THE DEFINITION OF HYPERTHYROIDISM?
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OVERPRODUCTION OF THYROID HORMONES BY THE THYROID GLAND
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WHAT IS THYROTOXICOSIS?
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EXCESS THYROID HORMONE FROM ANY CAUSE ACTING ON PERIPHERAL TISSUES
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WHAT IS THE PURPOSE OF RADIOACTIVE IODINE UPTAKE AND SCAN?
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WE USE IT TO NARROW THE DIFFERENTIAL DIAGNOSIS IN PATIENTS WITH SYMPTOMS OF HYPERTHYROIDISM---USED TO MEASURE FOCAL OR DIFFUSE CHANGES IN THYROID CELL FUNCTION OR ACTIVITY
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THE DISEASES THAT WILL HAVE HIGH RADIOACTIVE IODINE UPTAKE AND SCAN
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GRAVES DISEASE, TOXIC MULTINODULAR GOITER, TOXIC NODULE, AND DIETARY IODINE DEFICIENCY
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LOW RAIU AND SCAN
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SUBACUTE THYROIDITIS, THRYOID GLAND DAMAGE, ANTI-THYROID DRUG, EXCESS EXOGENOUS THYROID HORMONE, AND IODINE CONTAINING MEDICATIONS
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WHEN DO YOU ORDER A RAIU AND SCAN
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FOR PATIENT WHO HAVE S/S OF THYROTOXICOSIS, TO KNOW HOW MUCH RADIOIODINE TO USE FOR TX OF HYPERTHYROIDISM, TO EVALUTE SUSPICIOUS NODULE, TO LOCALIZE OR EXCLUDE MET CANCER
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NORMAL THYROID WILL UPTAKE HOW MUCH IODINE
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30%
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GRAVES DISEASE WILL UPTAKE HOW MUCH IODINE?
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SUCKS UP A WHOLE LOT
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HOW MUCH IODINE UPTAKE WILL THERE BE IN THYROIDITIS?
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ZERO B/C THE TISSUE IS INFLAMED
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HOW MUCH IODINE WILL A SINGLE COLD NODULE UPTAKE?
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NODULE IS NOT THYROID TISSUE SO IT WILL NOT UPTAKE IODINE
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S/S OF HYPERTHYROIDISM
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SWEATING, WEIGHT LOSS, HEAT INTOLERANCE, PALPITATIONS, RESTING TREMOR, RAPID RELAXATION IN DTR, MESTRIAL IRREGULARITY, WARM MOIST SKIN, TACHY, HTN, A FIB, LID LAG, GOITER IN GRAVES, OPHTHALMOPATHY, PRETIBIAL MYXEDEMA, LATE OSTEOPOROSIS
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LOCALIZED LESIONS OF THE SKIN FROM DEPOSITION OF HYALURONIC ACID FOUND HYPERTHYROIDISM
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PRETIBIAL MYXEDEMA
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CLINICAL ETIOLOGIES OF AN EXCESS AMT OF T4 AND T3
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GRAVES, ACUTE SUPPURATIVE THYROIDITIS, SUBACUTE THYROIDITIS, HASHIMOTOS THYROIDITIS, POSTPARTUM THYROIDITIS, PITUITARY TUMOR SECRETING EXCESS TSH
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MOST COMMON CAUSE OF THYROTOXICOSIS
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GRAVES DISEASE
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