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69 Cards in this Set
- Front
- Back
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Methsergide
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5HT2A adn 5HT2C ANTAGOINST--
proyhlatic treatment of migraines inhibit diarrhea associated with carcinoid sytnhe SE Retroperiotnal, pleural fibrosis--pursue treatment for 4 months, the take 1 month holdiday |
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Triptans
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5HT1A adn 5HT1B agoinsts
acute treatment of migrianes contraindicated in patients with ischemia heaert disease or varient angina |
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Ketanserin
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competive 5HT2A angtagoinst--no effect on migrane
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Retanserin
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competiive 5HT2A antagoinsts--NO effect on migrane
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Ondansetron
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5HT3 antagoinsts--prevent of N/V from cancer chemo
Se-diarrhea |
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Granisteron
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5HT3 antagoinsts--prevent of N/V from cancer chemo
SE--diarrhea |
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Alosteron
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5HT3 antagoinsts--IBS--SE consitaption
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CIlansetron
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5HT3 antagoinsts- IBS SE consitpation
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Tegaserod
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5HT4 AGOINST IBS, SE-diarrhea
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Prucalopride
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5HT4 AGOINST IBS, SE-diarrhea
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Egotmaine
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with caffiene--actue migranes
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Dihydroergotmaine
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treats acture migraines with caffiene
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Ergonovine
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conrol late urine bleeding during post-partum hemorrhage
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Bromocriptine
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pituitary tumors--excessive laction though DA agoinst
Dyskeinsase with parikin's disease acromegaly |
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What are Side effects of ergot alkaloids
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GI effects, and GANGEGRENE--ergonovine and ergotmaine
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What are drugs in treatment of Glucoma
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PGFa2 Tavoprost, Latanoprost and Bimatoprost
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Zarfilukast
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LTD4 LTE4 competive ANTAGOINST use in prevention and mangement of asthma, may also treat seonal allergic rinhitis and exercise induce asthma
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Montelukast
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LTD4 LTE4 competive ANTAGOINST use in prevention and mangement of asthma, may also treat seonal allergic rinhitis and exercise induce asthma
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Zileuton
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Inhibitor of 5-LO
use in prevention and mangement of asthma, may also treat seonal allergic rinhitis and exercise induce asthma |
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Side effects of Blockers of Leukotriene fuction
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HA, LIVER function tests
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Acetylated Salicultes
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ASA--irrvesilbe acetlates COX
analgesia, anti-inflammatory inhibition of platelt aggregion |
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Non-acetlyayed Saliculates
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Diflunisal
Salsalate Sodium Saliculate Choline Mg+ Tri Competive inhibitor of COX 3-4X in anti-inflammatoyr propties, LESS SEs, and NO ANTYPYRETIC acitvty |
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Therapetuic uses of Acetlayed and Non-acetlayted
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Analgesia and anti-inflammatory
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Major SE of Acetlayed and Non-acetlayted
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GI effects, Hepatic injry
Reye's Syndrome Increased bleeding time |
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MOA of Indomethacin
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inhibit polymorphonucle leukotcyes migration
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Properties of Indomethacin
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Lipophilic drug used in GROAP
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Indomethacin sucks in RA and OA, but it is first line for
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Acute gout and anklyosing spondylitis
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Sulindac
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metabolite poses therapetic, doesnt affect renal prostaglinds NO renal side effects use in GROA
Less SE than indomethacin |
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Ketorolac
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injectable, angesia eqaul to morphine w/o addition, HIGHLY ulcerogenic
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Etodolac
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No inhibitino of PGE2 syntheis decrease ulcers
Not effective for RA use in post-opteriatve procedures |
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Diclofenac
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accumates in synovial fluid, inhibt relase or utake of arachidonic acid in leuktocytes and potent inhibt of COX 1 and II< use ROA, and postopertive inflammation aftect acatact
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SE of Diclofenac
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increase hepatic transaminase acitvty, monitior aminotransferase activities
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Mefanmic acid and Mecofename
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SUCKS
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Prioxicam
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Inhibitrs both COX and neutrophil activation increase efficacy in arithis, adn Long half-life
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Meloicam
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Longer duration of action, similar to nabuemtone and COX II inhibiot
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Nambumetone
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Prodrug transformed in liver
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Celecoxib
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ROA, COX II specific inhbitor
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SE of Pyrazoles
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NO anti-platelt acity 4 fold less GI, RISK of stoke or heart attack
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Acetominphen, phenacetin
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NO anti-inflammotry effects--these compounds do not work in acidic environemnts
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GOLD (aurothiolglucose) gold sodium, auranofin
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inhibit the maturation and function of mononuclear phagocytes and can arrest progess and the disease and induce remission
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SE's of GOLD
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Skin and mucous membrane lesions (gray-blue pigmentation after expsoure to light)
GI effects Protenuira |
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Leflunomide
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pyrimidine synthsis inhibtior DHODH
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SE of Leflunomide
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SE greatest during 1st 2 weeks of therapy
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Azathiprine
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purine analog used as a chemotherapy agent inhibit the synthsis of inosinic acid
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SE Azthioprine
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bone marrow suppresion
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Cylophosphamide
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alklyating agent of the nitrogen mustard class
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SE of cylophoshamide
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bladder toxciity
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What are the Ant-TNFa therapies
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Adalimumab (humira)
Infliximab Etanercept |
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Adalimumab
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full human monoclonal antibody aganist TNF block cytokine inflammtion
sue RA refractory to DMARD |
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Inflixmab
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Mouse monoclonal antibody aginst TNFa inbhit inflamttion by blocking cytone netwek
RA and Cronh's disease |
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Enanerceptr
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bind to TNF and blocks it ability to ineract with receptor
RA and Cronhn's disease |
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What are Anti-IL 1 therapies
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Anakinra
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Anakinra
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IL-1 receptor antagoinst used in RA refratory to DMARD treat
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1st line therapy for gout
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NSAIDS
Glucorticoids |
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What are 2 NSAIDS that are preferred treatment for gout
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Indomethacin and Naproxen
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All NSAIDS treat gout by
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blocking PG synthesis
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What is MOA Indomethacin
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inhibits PMN migration, and increases uric acid secretion via kidneys
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What is MOA of prednisone
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inbhits
AP-1 NFKB |
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What are 2nd line treatments for GOUT
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Colchicine
Urcosuric agents (probenecid, sulfinpyrazle) Allopurinol |
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MOA of Colchicine
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inhibit UREA inflammation by binding to tublin and inhibit migration of neutrophils
inhibiting mitosis inbhiting LTB3 |
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Therapetic uses of Cochicine
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if administered within 12 hours of attack, or prophlactic treatment (small dose)
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SE of Colchicine
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80% GI
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What are MOA of Probenecid and sulfinpyrazone
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increases uric acid excretion in the proximal renal tubule
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Therapeutic uses of Probenecid and Sulfinpyrazone
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prophlayctic treatment ONLY
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SEs of Probencid and sulfinpyrzole
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increase gout attacks bc increase uric acid in kidneys--must drink lots of water
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Drug ineractions with Uricosuric agents
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Salcylates decrease the effectiveness b/c acdifiy urine
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MOA of Allopurinol
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block uric acid production by inhition of XO
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Therapeutic uses of Allopurinol
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high levels of uric acid
and recurrental renal stones |
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SE of Allopurinol
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increase gout attacts
cataracts GI |
