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37 Cards in this Set
- Front
- Back
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1. Purkinje fiber in cerebellum |
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1. CA1 pyramidal nerve in cortex |
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1. Substantia nigra |
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What Na channels are targets for drug development? |
1. NaV 1.8 and 1.9 |
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What Na channel is targeted by pufferfish toxin? |
1. NaV 1.7 |
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What is the a1 subunit in Ca channels? |
1. Gatekeeper protein |
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What are the B and a2 subunits in Ca channels? |
1. Auxiliary/modulatory subunits |
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What is the excitatory NT in the CNS? |
1. Glutamate |
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What is the function of acetylcholine? |
1. NM junction 2. SNS 3. ParaNS 4. CNS 5. EXCITATORY |
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Where does glycine play a role? |
1. Spinal cord |
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What will an excitatory NT do to the membrane potential? |
1. Drive it towards 0---- depolarization |
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What will an inhibitory NT do to membrane potential? |
1. Hyperpolarize 2. GABA PRINCIPALLY |
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How does glycine work with glutamate? |
1. Co-activator of NMDA receptors 2. Both glutamate and glycine required for activation |
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Where does ketamine bind? |
1. NMDA receptor
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What is the state of NMDA receptors at rest? |
1. Blocked by Mg 2. AMPA receptors activated, depolarize membrane 3. Mg displaced from NMDA---- channel is activated |
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In what process are NMDA receptors involved (one of many)? |
1. Learning |
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What drugs target the NMDA receptor? |
1. Memantine--- Alzheimer's 2. Ketamine--- anesthesia |
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What substances can bind to GABA receptors? |
1. Propofol 2. Sevoflurane 3. Ehtanol 4. Benzos 5. GABA 6. Barbiturates 7. Neurosteroids |
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What is released from GABA receptors when they are stimulated? |
1. Cl |
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What is the use of benzodiazepine? |
1. Anxiolytic 2. Sedative |
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What is flumazenil? |
1. Benzodiazepine antagonist |
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What is pentobarbital? |
1. Antiepileptic 2. Sedative |
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What are propofol and sevoflurane? |
1. Hypnotic anesthetics |
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What does capsaicin activate? |
1. TRPV1 channels--- nociception 2. Na ions enter cells |
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Where are TRPV1 channels located? |
1. C fibers, A delta fibers in dorsal horn of spinal cord
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What activates TRPV channels? |
1. Heat |
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What activates TRPM? |
1. Cold---- menthol |
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What induces TRPA? |
1. Pain 2. Garlic, mustard oil, tear gas |
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What TRP channel has the highest activation temperature? |
1. TRPV2--- 55 C |
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What is the MOA of 4-aminopyridine? |
1. KV blocking drug in demyelinated axons 2. Used to improve movement in MS patients |
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What is the MOA of amiodarone? |
1. Block Kv11 |
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What is the MOA of sevoflurane? |
1. Activation of K2P channels along with GABA channels |
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What NTs lead to EPSPs? |
1. Ach 2. Glutamate |
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What NTs lead to IPSPs? |
1. Glycine 2. GABA |
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What is the primary non-NMDA channel activated by glutamate? |
1. AMPA |
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What is the role of AMPA? |
1. Primary mediator of fast excitatory synaptic transmission in the CNS |
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What blocks TRPA? |
1. Propofol |
