Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
What is a drug?
|
an agent that alter the rate or extent of a biological process
|
|
|
What is a receptor
|
biological molecule whose function is modulated by chemical combination with the drug
|
|
|
What are some exxample of drugs receptor
|
Ion hcannel, transproter, enzyme
|
|
|
What is drug potency?
|
THe amount of a drug required to elicit a certain biological response Usually smaller the dose, the greater the potentcy
|
|
|
What is affinity
|
the attractive force between substance that cause them to enter into and remain in chemical combinationw
|
|
|
hat is chemotherapy
|
using chemical not created in the boy to fight diseaese
|
|
|
what is magic bullet
|
a drug that can kill microbes but not the person wiht the disease
|
|
|
What is lock and key
|
the idea that a drug molecule has a shape that fits the shape of the receptor//
|
|
|
What is pharmacodynamic
|
the study ofinteraciton between drug and drug receptor
|
|
|
What weak forces is involved in the drug receptor binding
|
1. ionic
2. hydrogen, 3. vander wall 4. hydrophobic force |
|
|
What is the recepter occupancy theory
|
koff<- D + R -> DRk on At eq: k1D*R = k2 = DR |
|
|
what is the equilibrium constant
|
K-1/k1 = kd mole /L
|
|
|
What is kd?
|
the equilibrium disassociation constant = drug at which 50% of the drug receptors are occupied
|
|
|
What is kd apparent,
|
it is 50% to get biological response by a drug
|
|
|
What is the relationship between potency and affinity
|
The potency of a drug is primarily a consequence of its affinity for a specific receptro
|
|
|
What is an agonist:
|
a exogenous or endogenous compoudn that produce a biological response when bind to a receptor
|
|
|
what is antagonist
|
binds to the site but does nothing on its ownw
|
|
|
what is competitive antagonism?
|
When its binds to the same site as the agonist, and it shifts to the right basically compete for the site.
|
|
|
What is noncompetitive antagonism?
|
Binds reversible to allosteric site or same asite as agonis which basically turns off the receptor to preventgeting maximum respomse
|
|
|
What are the three occupancy assumption
|
1. fix receptors and the number of receptors is fixed
-not likely because it mgiht pop up more depending if its sensitive 2. biological response is prort to the occupancy of the receptor. spare and extra 3. cocentration of free drug at the receptor iste is same as drug concentration in the blood nope cause of the membranes |
|
|
What are extra receptors?
|
basically u need alot more than 50% of the occupancy to induce 50%
|
|
|
What is spare receptor?
|
you need maye only 1% of hte receptor binding to get max response.
If when with irreversible inhibito, ilooks like a competitive but eventually ower the response |
|
|
What is qsar?
|
1. find the target
2. map the active site 3. find toxic and desire drug effect 4. search for a more potent drug 5. basically you want to see what the site looks like so you can get a good feeling of whats a good structure for a drug |
|
|
etra
|
qsar can be used to increase the potency of an excisting drug by fixing what it looks like.
|
|
|
hi
|
hi
|
