Intro To Pharm

Front 1

Most important properties of an ideal drug?

Back 1

-effectiveness
-safety
-selectivity

Front 2

Factors that determine the intensity of drug responsiveness?

Back 2

-administration
-pharmacokinetics
-pharmacodynamics
-sources of individual variation

Front 3

4 basic processes of pharmacokinetics?

Back 3

1) absorption
2) distribution
3) metabolism
4) excretion

Front 4

Maximal efficacy

Back 4

Largest effect that a drug can produce

Front 5

Relative potency

Back 5

Amount of a drug that must be given to produce an effect

Front 6

4 primary receptor families:

Back 6

1) cell membrane-embedded enzymes
2) ligand-gated ion channels
3) G protein-coupled receptor systems
4) transcription factors

Front 7

Intrinsic activity

Back 7

the ability of a drug to activate the receptor after binding

Front 8

Agonists

Back 8

-molecules that activate receptors
-bind to receptors and mimic the actions of body's own regulatory molecules
-affinity and high intrinsic activity

Front 9

Affinity

Back 9

the strength of attraction between a drug and its receptor

Front 10

Antagonists

Back 10

-prevent receptor activation by endogenous molecules and other drugs
-have affinity but no intrinsic activity
-work against agonists
-2 types:
-noncompetitive: bind irreversibly
to receptors
-competitive: bind reversibly to
receptors

Front 11

idiosyncratic effect

Back 11

uncommon response to a drug due to genetic predisposition

Front 12

iatrogenic disease

Back 12

disease produced a drug