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26 Cards in this Set
- Front
- Back
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What are the four types of receptors?
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Voltage gated Na
Voltage gated K Ligand gated Nicotinc AcH Ligand gated Glycine |
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What does voltage gated Na receptor do?
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Block channel from outside
Increasing paralysis |
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What does voltage gated K receptor do?
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Blocks big calcium activated K channel
Muscle paralysis |
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What does ligand-gated nicotinc AcH receptor do?
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Block receptor at NMJ
Increased muscle relaxation/paralysis |
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What does ligand gated glycine receptor do?
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Competitive antagoinst
Muscle spasms |
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Which receptors require ions to enter cell quickly?
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Ligand-gated
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Which receptors require a G-protein?
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Ligand-gated
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Which channel depends on membrane potential?
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Voltage gated
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What are the two types of synaptic transmission?
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Excitatory
Inhibitory |
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What are the 4 monoamine NTs?
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Dopamine
Norepinephrine 5-Hydroxytryptamine (5HT =serotonin) Substance P |
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What are the 2 amino acid NTs?
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Glutamine
GABA |
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Glutamate acts on which receptor?
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NMDA
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Binding to NMDA receptors require?
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Mg+2 block
Glycine binding |
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Glutamine is an (inhibitory/excitatory) NT?
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Excitatory
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Binding to NMDA receptors make what more prememable to neurons?
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Ca2+, Na+, K+
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GABA is an (inhibitory/excitatory) NT?
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Inhibitory
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GABA makes neuron selectively permeable to?
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Cl-
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AcH action are mediated by
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GPCR Muscarinic receptors
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How many muscarinic receptors are there?
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M1-M5
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Odd numbered muscarinic receptors are
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Gq --> increased by IP3 and DAG
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Even numbered muscarinic receptors are
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Gi --> decreased adenlyl cyclase and cAMP
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What is the rate limiting step in dopamine synthesis?
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Tyrosine
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D1-like dopamine receptors do what?
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Gs, increases cAMP
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D2 like dopamine receptors do what?
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Gi, decrease cAMP
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What are the 3 dopamine pathways?
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Nigrostriatal pathway
mesocortical pathway tuberinfundibular pathway (inhibitor of prolactin) |
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What is things are nor permebable to the BBB?
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Charged molcules, non-liphophilic drugs
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