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18 Cards in this Set

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Intimidators
Tolazoline
Phentolamine
trigger tachycardia
some reverse action of sympatholytics when dealing with toxicity of alpha agonists
tolazoline
Phentolamine
Non selective Alpha blockers treat what
hypertension
BPH
Hypovolemic shock
Peripheral vascular disease
Water soluble-salts
Imidazolines trx what
cardiospasms in blood vessels, pulmonary HTN in newborns, Hypertension emergencies due to MAO therapy or to tx sexual dysfunction.
No intrinisic activity b/c they are blockers
No reflex tachycardia
Quinazolines
Orthostatic hypotension
Prazosin
insoluble in water and 4 active metabolites
Prazosin
More soluble
Terazosin
Metabolism is less, longer half-life
Terazosin
1 active metabolite, 3 inactive metabolites
Terazosin
short-acting selective alpha 1 receptor antagonist
Alfozosin/Tamsulosin
Low incidence of hypotension/sexual dysfunction
Alfozosin, Tamsulosin
rapidly absorbed from GIT, but poorly penetrates CNS
Alfozosin, Tamsulosin
same distance as phenylethylamines
Clonidine
rip ring open-cmp still active
Clonidine
non-coplanar
Clonidine
Guanfacine
equipotent
Guanabenz
less potent, shorter duration