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18 Cards in this Set
- Front
- Back
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Intimidators
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Tolazoline
Phentolamine |
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trigger tachycardia
some reverse action of sympatholytics when dealing with toxicity of alpha agonists |
tolazoline
Phentolamine |
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Non selective Alpha blockers treat what
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hypertension
BPH Hypovolemic shock Peripheral vascular disease Water soluble-salts |
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Imidazolines trx what
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cardiospasms in blood vessels, pulmonary HTN in newborns, Hypertension emergencies due to MAO therapy or to tx sexual dysfunction.
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No intrinisic activity b/c they are blockers
No reflex tachycardia |
Quinazolines
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Orthostatic hypotension
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Prazosin
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insoluble in water and 4 active metabolites
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Prazosin
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More soluble
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Terazosin
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Metabolism is less, longer half-life
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Terazosin
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1 active metabolite, 3 inactive metabolites
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Terazosin
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short-acting selective alpha 1 receptor antagonist
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Alfozosin/Tamsulosin
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Low incidence of hypotension/sexual dysfunction
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Alfozosin, Tamsulosin
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rapidly absorbed from GIT, but poorly penetrates CNS
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Alfozosin, Tamsulosin
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same distance as phenylethylamines
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Clonidine
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rip ring open-cmp still active
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Clonidine
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non-coplanar
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Clonidine
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Guanfacine
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equipotent
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Guanabenz
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less potent, shorter duration
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