Internal Medicine - Up To Date

Front 1

ITP in adults
Differential diagnosis for thrombocytopenia without other cytopenias

Back 1

TTP-HUS and DIC, gestational thrombocytopenia (pregnant women), drug-induced thrombocytopenia, HIT, infection, hypersplenism (2' portal HTN), myelodysplasia, acquired pure megakaryocytic aplasia

Front 2

ITP in adults
Most common cause of drug-induced thrombocytopenia in adults?

Back 2

Quinine (for treatment of uncomplicated chloroquine-resistant P. falciparum malaria)

Front 3

ITP in adults
When should you treat? What is the 1st line treatment?

Back 3

Treat when platelets < 30k or patient is severely bleeding
1st Line treatment - corticosteroids (prednisone), IVIG, and anti-RhD (only if patient is Rh+)

Front 4

ITP in adults
Initial therapy didn't work. What is the 2nd line treatment?

Back 4

Splenectomy is the most preferred 2nd line treatment. Then, rituximab (Rituxan) - mab against CD20 B cells

Front 5

ITP in adults
1st and 2nd line treatments aren't working, now what?

Back 5

TPO (thrombopoiesis stimulating agents) may help - e.g. romiplostim, eltrombopag)

Front 6

Wiskott-Aldrich Syndrome Triad

Back 6

X-linked thrombocytopenia, low IgM (high IgA and IgE) and recurrent infections

Front 7

Alport Syndrome Triad

Back 7

Giant platelets, hereditary nephritis (renal failure) and hearing loss

Front 8

Fanconi Syndrome Triad

Back 8

Short stature, anemia (inherited aplastic anemia), and neutropenia

Front 9

Reye syndrome
What is it? Gimme a quick 5 sentence summary of the syndrome.

Back 9

Reye syndrome is a rapidly progressive encephalopathy with hepatic dysfunction characterized by vomiting and confusion, evolving to seizures and coma. Labs show elevated aminotransferase activity, increased PT, hyperammonemia, hypoglycemia, and metabolic acidosis. Increased ICP is an important contributor to morbidity and mortality. ASA use is a risk factor especially in cases with varicella or influenza. Associated with deficiency of medium chain acyl-coenzyme A dehydrogenase and other fatty acid oxidation disorders, and urea cycle disorders.