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12 Cards in this Set

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Acetylsalicyclic acid (Aspirin)
Indomethacin (Indocin)
Meloxicam (Mobic)
Ibuprofen (Motrin, Advil)
Naproxen (Naprosyn)
Ketorolac (Toradol)

Class?
AE?
AEs specific for aspirin?
Acetylsalicyclic acid (Aspirin)
Indomethacin (Indocin)
Meloxicam (Mobic)
Ibuprofen (Motrin, Advil)
Naproxen (Naprosyn)
Ketorolac (Toradol)

Class: NSAID (Non-steroidal anti-inflammatories)

AE:Bleeding, gastric distress, heartburn, nausea, gastric ulceration, sweating, headache, hypothermia

AE specific to aspirin: the above + aspirin induced hypersensitivity (salicylism), tinnitus, Reye's syndrome (children)
Acetylsalicyclic acid (Aspirin)

Class?
Indications?
MOA?
Class: NSAID

Indication: "*gold standard, reduce inflammation and fever, produce analgesia, pain reliever, used as blood thinner to prevent MI
*rheumatoid arthritis therapy treats symptoms only (higher dose, more adverse effect)

MOA: Irreversible inhibitor of COX I & II; Prevents synthesis and release of prostaglandins by interrupting the cyclooxygenase pathway
Indomethacin (Indocin)
Meloxicam (Mobic)
Ibuprofen (Motrin, Advil)
Naproxen (Naprosyn)

Class:
Indication:
MOA:
Indomethacin (Indocin)
Meloxicam (Mobic)
Ibuprofen (Motrin, Advil)
Naproxen (Naprosyn)

Class: NSAIDs

Indication: reduce pain, fever, inflammation, used for rheumatoid arthritis, gouty arthritis, osteoarthritis, and other inflammatory disease


MOA: reversible, nonspecific inhibitor of COX I & II
Ketorolac (Toradol)

Class?
Indication?
MOA?
Why different from other NSAIDs
Ketorolac (Toradol)

Class: NSAID

Indication: short term management of pain and severe post-op pain

MOA: Inhibits protaglandin synthesis, producing peripeherally mediated analgesia

Not recommended for >5 days due to liver toxicity; reserved for post-op analgesia
Acetaminophen (Tylenol)

Indication?
MOA?
Caution due to?
Acetaminophen (Tylenol)

Uses: Cold medicine, reduce pain and fever, general systemic action

MOA: Weak prostaglandin synthetase inhibition in the CNS

Can cause hepatoxicity
Celecoxib (Celebrex)

Class?
Indication?
MOA?
AE/Caution?
Celecoxib (Celebrex)

Class: COX II inhibitor

Indication: analgesia; Reduces inflammatory prostaglandins while sparing those that protect the stomach, reduce pain, inflammation- arthritis

MOA: Selective blockade of cyclooxygenase II enzyme (4th line agent)

AE: Increased risk of CV problems/CVA
Morphine
Codeine
Hydromorphone (Dilaudid)
Hydrocodone w/ acetaminophen (Lorcet, Vicodin)
Oxycodone (Roxicodone)
(with acetaminophen Percocet)

Class?
MOA?
AE?
Which from above list are strong agonists? (2)
Which is used for pain relief associated w/an MI?
Which is most potent when given orally?
Class: Opoids

MOA: inhibition of K+ channels @ mu & kappa opiod receptors, inhibiting release of substance P

AE: respiratory depression, constipation, urinary retension, orthostatic hypotension, increased intracranial pressure, sedation, miosis

Strong agonists: Morphine, hydromorphone (Diaudid)

Morphine used w/MI

Hydromorphone (Dilaudid) more potent than morphine when given PO
Meperidine (Demerol)
Fentanyl (Duragesic)
Methadone (Dolophine)
Propoxyphene (Darvon)

Class?
MOA?
AE?
Which from above list is a strong agonists? (1)
Which has multiple methods of administration?
Which is used to aid heroin addicts with withdrawal symptoms?
Class: Opoids

MOA: inhibition of K+ channels @ mu & kappa opiod receptors, inhibiting release of substance P

AE: respiratory depression, constipation, urinary retension, orthostatic hypotension, increased intracranial pressure, sedation, miosis

Fentanyl is a strong agonist & has multiple methods of administration (patches, lollipops, IV, PO)

Methadone is used to wean heroin addicts and help avoid w/drawal symptoms
Tramadol (Ultram)

Indication?
MOA?
AE?

Name when tramadol is combined w acetominophen?
Tramadol (Ultram)

Indication: Analgesia, decrease moderate to moderately severe pain

MOA: binds to mu -opioid receptors and inhibits reuptake of NE and 5HT

AE: eizures, dizziness, headache, constipation, N/V/D, pruritus, sweating, tolerance,
seizure, suicide, serotonin syndrome, anaphylactic shock, respiratory depression, drug interactions with alcohol, CNS depressant, dependence, withdrawal

Ultracet is tramadol 37.5mg + acetaminophen 325mg-used for short term management of acute pain. MOA & AE the same as tramdol + that of acetamin
Lidocaine (Lidoderm)

General indication?
Indication as a cardiac med?
AE?
Indication: local analgesia
Cardiac: used for ventricular arrhythmia

MOA: stabilizes neuronal membranes; inhibits ion fluxes required for initiation and conduction of pain impulses

AE: seizure, confusion, drowsiness, decreased mucosa,cardiac arrest, N/V, bronchospasm, stinging, anaphylaxis
Nalbuphine (Nubain)
Butorphanol (Stadol)

Class?
Indication?
MOA?
AE?
Which is available as a nasal spray?
Nalbuphine (Nubain)
Butorphanol (Stadol)

Class: mixed opioid agonist & antagonist

Indication: analgesia without as much potential for abuse & fewer AE

MOA: Acts as agonist @ kappa receptors and antagonist @ mu

AE: sedation, respiratory depression, dry mouth, N/V, urinary urgency, confusion

Butophanol (Stadol) is available as a nasal spray for migraines
Name an opiate antagonist.

What is it used for?

What is its MOA?

AE?
Naloxone (Narcon)

Indication: Treatment for acute opiod overdose; reverses analgesia and respiratory depression

MOA: Competitively binds to opiate receptors(mu) and prevents bind ing of agonists

AE: ventricular arrhythmias, N/V, HTN/hypotension