Integ Review Final

Front 1

Isotretinoin (Accutane)

Back 1

at high doses, can indirectly increase the concentration of P. acnes

Front 2

Propecia (Finasteride)

Back 2

a testosterone analogue that inhibits 5-α reductase for androgenic alopecia

Front 3

Malignant Melanoma

Back 3

a cutaneous neoplasm that arises from epidermal melanocytes de nove or preexisting nevus; most important clinical sign is changes in color of the pigmented lesion; borders of lesion are irregular and notched; ABCDE rule

Front 4

4 types of malignant melanoma?

Back 4

-Lentigo Maligna Melanoma
-Superficial Spreading Melanoma
-Nodular Melanoma
-Acral Lentiginous Melanoma

Front 5

Superficial Spreading Melanoma

Back 5

most malignant; relatively flat topped pigmented papule or plaque; irregular borders and pigmentation; bumpy and lobulated

Front 6

Growth Phases of Malignant Melanoma

Back 6

Radial growth phase and Vertical growth phase

Front 7

Radial growth phase of Malignant Melanoma?

Back 7

tendency to grow horizontally within epidermal and superficial dermal layers; no metastasis; Lentigo Maligna Melanoma and Lentiginous Melanoma

Front 8

Vertical growth phase

Back 8

tendency to grow downward into deeper dermal layers; metastasis; Nodular Malignant Melanoma

Front 9

Corticosteroids

Back 9

anti-inflammatory & immunosuppressant activities

Front 10

Good prognosis in Malignant Melanoma?

Back 10

when tumor infiltrating lymphocytes in extremeties

Front 11

bad Prognosis in Malignant Melanoma?

Back 11

when vertical growth phase with increased number of mitotic spindles

Front 12

Dysplastic Nevi

Back 12

an abberant differentiation of benign nevi characterized by abnormal growth pattern and cytologic abnormality of melanocytes

Front 13

Squamous Cell Carcinoma

Back 13

tumor associated with excessive exposure to sunlight; carcinoma in situ with sharply defined red scaling plaques; invasive lesions that are nodular, ulcerated, hyperkeratotic; appear on hands and face; all levels of epidermis

Front 14

Basal Cell Carcinoma

Back 14

a slow growing tumor that rarely metastasizes that occurs in sun exposed areas especially in light pigmented people; rolled edges with central ulceration; pearly papules and telangiectasias; rodent ulcers; abnormalities of bone, nervous system, eyes, reproductive system; proliferating basal cells from epidermis into dermis

Front 15

types of Basal Cell Carcinoma?

Back 15

-Superficial Basal Cell Carcinoma
-Nodular Basal Cell Carcinoma
-Pigmented Basal Cell Carcinoma
-Morpheaform Basal Cell Carcinoma

Front 16

Morpheaform Basal Cell Carcinoma

Back 16

sclerosing; firm white or yellowish plaque with ill-defined border; no ulceration; induration; enlarging scar

Front 17

Cutaneous Histiocytosis X

Back 17

proliferation of Langerhan cells in skin & lymph node

Front 18

Mycosis fungoides

Back 18

associated with presence of malignant T cells in peripheral blood and erythematous scaling of body surface

Front 19

Xanthoma

Back 19

associated with aggregates of histiocytes with foamy cytoplasm and the presence of Touton giant cells

Front 20

Pt presents with h/o slow growing nodule on upper eyelid. Histo exam of pearly nodule shows nests of small cells with radial arrangement at periphery, and there is infiltration of epidermis into dermis. Most likely diagnosis is:

Back 20

BCC = basal cell carcinoma

Front 21

What type of skin cancer responds to imiquimod (Aldara)?

Back 21

Superficial type BCC (basal cell carcinoma)

Front 22

Resection of the involved regional lymph node(s) is required for:

Back 22

Congenital hairy nevus overlying axillary nodes (Brewslow 1.80 mm into
reticular dermis).

Front 23

Telangiectasias

Back 23

serpiginous, threadlike red lesions which blanch on diascopy

Front 24

Black pt presents w/ pigmented streak on left thumbnail plate that’s been there for several months & is growing. It’s asymptomatic & irregular in width. Biopsy shows:

Back 24

SCC = squamous cell carcinoma

Front 25

In ABCDE melanoma classification, what does B stands for?

Back 25

border.

Front 26

Ship captain has multiple oval-to-round brown macules on back of forearms and dorsum of hands. These lesions are called:

Back 26

Solar lentigines

Front 27

Pt presents w/ dome-shaped, reddish, smooth, firm nodule w/ central crust. This lesion is on forehead, is slowly enlarging, and there’s extensive sun damage around the lesion. Most likely diagnosis is:

Back 27

SCC = squamous cell carcinoma

Front 28

Pt presents w/ waxy, white-to-yellow lesion on left cheek x 1 year. PE shows sclerotic plaque w/ indistinct margins and telangiectasias. Most likely diagnosis is:

Back 28

Morpheaform BCC (basal cell carcinoma)

Front 29

Granulation tissue

Back 29

product of secondary healing/ proliferative phase. Includes proliferation of capillaries & inflammatory cells. "proud flesh" not bad if no pus. (Sign of healthy wound healing)

Front 30

Clean wound

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<100,000 organisms per gram of tissue

Front 31

Inflammatory phase of wound healing:

Back 31

Also known as substrate phase. No collagen, but Mφ and PMNs present. Monocytes --> macrphages (secrete MDGF)

Front 32

How are burns classified?

Back 32

the depth of injury. Partial-thickness burn wounds vary in the amount of pain.

Front 33

Most common bacterias infecting burn wounds

Back 33

Staph & Strep

Front 34

Initiation of treatment for burn patient?

Back 34

first stop the burning process.

Front 35

Diabetes mellitus increases the incidence for __________

Back 35

wound infection.

Front 36

An example of contaminated wound requiring surgery :

Back 36

Colon resection for ruptured diverticulum

Front 37

CREST syndrome is best characterized by what?

Back 37

Calcinosis.

Front 38

Important SLE feature

Back 38

false (+) syphilis serology

Front 39

Most common presenting feature in scleroderma (progressive systemic sclerosis):

Back 39

Raynaud’s phenomenom

Front 40

Clinically, glucocorticoids are most likely used for:

Back 40

Inhibiting formation of prostaglandins

Front 41

Topical glucocorticoids have the beneficial effect of:

Back 41

Causing atrophy of hypertrophic scars

Front 42

Chemical peels are used to treat

Back 42

hyperpigmentation psoriasis

Front 43

Sclerotherapy

Back 43

is indicated for varicose & telangiectic veins

Front 44

The best topical acne therapy?

Back 44

Clindamycin.

Front 45

A common and effective keratolytic agent?

Back 45

α-hydroxy acids (fruity acids)

Front 46

what is PUVA used for?

Back 46

Psoriasis.