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16 Cards in this Set
- Front
- Back
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cleavage of what between chain A and B eliminates activity
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S-S
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deletion of what from the Beta chain will cause no change in activity
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PHE and VAL from the N terminal end
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deletion of what from the alpha chain will decrease activity
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GLY
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removing C terminal ALA from Beta chain of Pork or Beef does what to activity
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doesnt alter activity
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how many AA is in proinsulin, preproinsulin, and insulin
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proinsulin = 86
preproinsulin = 109 insulin = 51 |
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how is Lisipro made
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AA 28 and 29 are transposed in the Beta chain
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how is Aspart made
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AA 28 on the Beta chain is transposed with Asp
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how is Glulisine made
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AA 3 (Val) on Beta chain is replaced w/ Lys and AA 29 (Lys) on the Beta chain is replaced with Glu
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how many AA are in the Beta and Alpha chain of insulin
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A: 21
B: 30 |
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how do the C peptides in pork, beef, and human insulin compare
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all varieties of insulin have different amount of AA in the C peptides compared to human insulin
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what is the properties of rapid acting insulin
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faster onset shorter duration and less absorption variation
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what can be substituted at R for 1st gen
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Br, Cl, I, SCH3, CF3, COCH3, NH2, CH3
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what can be substituted at the R' for 1st gen
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Aryl, NCH3, NC2H5
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what does Aryl Sub do to 1st gen
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toxic
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what does NCH3 sub do to 1st gen
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inactive
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what does NC2H5 sub do to 1st gen
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low activity
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